中华卷柏木脂素类化学成分研究  

Chemical constituents of lignans from Selaginella sinensis

作　　者：陈熹 任琴 刘阳[2] 邹振兴 徐康平 谭桂山 CHEN Xi;REN Qin;LIU Yang;ZOU Zhen-xing;XU Kang-ping;TAN Gui-shan(Xiangya School of Pharmaceutical Sciences,Central South University,Changsha 410013;Xiangya Hospital,Central South University,Changsha 410008)

机构地区：[1]中南大学湘雅药学院,长沙410013 [2]中南大学湘雅医院,长沙410008

出　　处：《中南药学》2020年第1期11-14,共4页Central South Pharmacy

基　　金：国家自然科学基金项目(No.31700303)

摘　　要：目的研究中华卷柏中木脂素类化合物。方法采用硅胶、聚酰胺、LH-20柱色谱和半制备高效液相等现代色谱分离技术对中华卷柏75%乙醇提取液进行分离纯化,根据化合物的理化性质和波谱数据进行结构鉴定。结果从中华卷柏75%乙醇提取液中分离并鉴定了4个木脂素类化合物,分别为(7R,8S)-ceplignan(1)、2,3-trans-3,4-trans-2-methoxy-3-hydroxymethyl-4-[bis-(4-hydroxyphenyl)methyl]tetrahydrofuran(2)、(8S,8'R,7'R)-[tetrahydro-5-(3-hydroxy-4-methoxyphenyl)-4-(hydroxymethyl)-3-furanyl]-3-hydroxy-4-methoxyphenyl-methanone(3)、(+)-isolariciresinol(4)。结论化合物1、3、4是首次从该植物中分离得到,化合物3是首次在卷柏属植物中被发现。Objective To determine the chemical constituents in Selaginella sinensis(Desv.)Spring.Methods Selaginella sinensis was extracted by 75%ethanol,followed by isolation and purification with column chromatography over silica gel,polyamide,Sephadex LH-20,and semi-prepared high performance liquid phase(ODS).The compounds structures were elucidated by physicochemical properties and spectroscopic methods.Results Four lignans were obtained and identified as(7R,8S)-ceplignan(1),2,3-trans-3,4-trans-2-methoxy-3-hydroxymethyl-4-[bis-(4-hydroxyphenyl)methyl]tetrahydrofuran(2),(8S,8'R,7'R)-[tetrahydro-5-(3-hydroxy-4-methoxyphenyl)-4-(hydroxymethyl)-3-furanyl]-3-hydroxy-4-methoxyphenyl-methanone(3),and(+)-isolariciresinol(4).Conclusion For the first time,compound 1,3 and 4 are separated from this plant,while compound 3 from genus Selaginellacea.

关 键 词：卷柏属 中华卷柏 化学成分 木脂素 

分 类 号：R284[医药卫生—中药学]