中药外敷联合红花黄色素氯化钠注射液治疗胸腔积液临床研究  

Clinical Study on External Application of Chinese Medicine Combined with Safflower Yellow and Sodium Chloride Injection for Pleural Effusion

作　　者：范正业 张英巧 张建安 尹义学 FAN Zhengye;ZHANG Yingqiao;ZHANG Jian’an;YIN Yixue

机构地区：[1]陇南市第一人民医院

出　　处：《新中医》2020年第1期76-79,共4页New Chinese Medicine

摘　　要：目的:观察大黄当归外敷方联合红花黄色素氯化钠注射液治疗胸腔积液的临床疗效,及其对积液中血管内皮生长因子(VEGF)水平的影响。方法:将120例胸腔积液患者随机分为中药组、红花黄色素氯化钠注射液组(注射液组)、联合组以及对照组,每组30例;中药组给予大黄当归外敷方外敷治疗,注射液组给予红花黄色素氯化钠注射液治疗,联合组给予中药外敷联合红花黄色素氯化钠注射液注射治疗,对照组给予反复穿刺抽液治疗;2周后评价4组临床疗效,统计治疗前后生活质量评分,检测积液中VEGF水平变化。结果:治疗后,联合组、中药组、注射液组、对照组的总有效率分别为93.33%、86.57%、83.33%、36.67%。其中联合组疗效最好,与中药组、注射液组、对照组两两比较,差异均有统计学意义(P<0.05);中药组、注射液组与对照组比较,差异亦有统计学意义(P<0.05);中药组与注射液组比较,差异无统计学意义(P> 0.05)。治疗后,各组VEGF水平均较治疗前明显降低,差异有统计学意义(P<0.05);联合组、注射液组、中药组VEGF水平均低于对照组(P<0.05);联合组、注射液组VEGF水平低于中药组(P<0.05);联合组VEGF水平低于注射液组(P<0.05)。治疗后,各组生活质量评分均较治疗前明显升高,差异有统计学意义(P<0.05);且联合组、中药组、注射液组评分高于对照组(P<0.05);联合组评分高于中药组、注射液组(P<0.05);中药组评分高于注射液组(P<0.05)。结论:中药外敷法联合红花黄色素氯化钠注射液治疗胸腔积液效果显著,可显著降低积液中VEGF水平,提高患者生活质量。Objective: To observe the clinical effect of rhubarb and angelica sinensis external applicationprescription combined with safflower yellow and sodium chloride injection for pleural effusion and its effect on the levels of vascular endothelial growth factor(VEGF) in the effusion. Methods:Divided 120 cases of patients with pleural effusioninto the Chinese medicine group,the safflower yellow and sodium chloride injection group(the injection group),the combination group and the control group randomly,with 30 cases in each group;the Chinese medicine group was given theexternal applicationof rhubarb and angelica sinensis external applicationprescription;the injection group was givensafflower yellow and sodium chloride injection;the combination group was treated with the external application of Chinese medicine combined withsafflower yellow and sodium chloride injection;the control group was treated with repeated thoracic drainage;after 2 weeks,evaluated the clinical effectin the four groups,recorded the scores of the quality of life in the four groups before and after treatment and detected the changes of VEGF levels in the effusion. Results:After treatment,the total effective rate was 93.33% in the combination group,86.57% in the Chinese medicine group,83.33% in the injection group and 36.67% in the control group. Among which,the combination group had the best curative effect and there were significant differences being found in the pairwise comparison with the Chinese medicine group,the injection group and the control group(P < 0.05);there was also significant difference being found in the comparison between the Chinese medicine group and the injection group and the control group(P < 0.05);there was no significant difference being found in the comparison between the Chinese medicine group and the injection group(P>0.05). After treatment,VEGF levels in all the groups wereobviously-decreased when compared with those before treatment, difference being significant(P < 0.05);VEGF levels in the combination group, the injec

关 键 词：胸腔积液 大黄当归外敷方 红花黄色素氯化钠注射液 外敷 VEGF 

分 类 号：R561[医药卫生—呼吸系统]