类风湿性关节炎患者anti-Sa、anti-CCP抗体浓度检测及其与炎症及骨关节损伤严重程度的相关关系  

Detection of anti-Sa and anti-CCP antibodies in patients with rheumatoid arthritis and their correlation with inflammation and severity of bone and joint injury

作　　者：牛诗琼 邓绍团 张姹慧 王宇苗 罗招凡[1] NIU Shi-qiong;DENG Shao-tuan;ZHANG Cha-hui;WANG Yu-miao;LUO Zhao-fan(Clinical Laboratory,the Seventh Hospital Affiliated to Sun Yat-sen University,Shenzhen,Guangdong 518000,China;不详)

机构地区：[1]中山大学附属第七医院检验科,广东深圳518000 [2]深圳市宝安区人民医院生殖医学科,广东深圳518000 [3]香港大学深圳医院护理部,广东深圳518000

出　　处：《中国卫生检验杂志》2020年第1期83-86,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的检测类风湿性关节炎(RA)患者血清中抗环状瓜氨酸(anti-CCP)抗体、抗Sa(anti-Sa)抗体浓度,探讨其与机体炎症及骨关节损伤程度的内在联系。方法选择2014年1月-2018年5月首次确诊并接受治疗的RA患者129例作为RA组,同期进行体检的健康志愿者100例作为对照组。检测2组血清anti-Sa、anti-CCP抗体浓度以及血清炎症因子含量、骨关节损伤评分及相关指标含量,采用Pearson检验评估RA患者血清anti-Sa、anti-CCP抗体浓度与机体病情严重程度的相关关系。结果RA组患者血清anti-Sa、anti-CCP抗体浓度高于对照组(P<0.05)。RA组患者血清炎症因子肿瘤坏死因子-α(TNF-α)、白介素-17(IL-17)、白介素-22(IL-22)、白介素-37(IL-37)的含量高于对照组,Lysholm评分、HSS评分值低于对照组,血清中骨关节损伤相关指标护骨素(OPG)、核因子-κB受体活化因子配体(RANKL)、基质金属蛋白酶3(MMP3)的含量高于对照组(P<0.05)。相关性分析显示,RA患者血清anti-Sa、anti-CCP抗体浓度与血清炎症因子及骨关节损伤相关指标含量呈正相关(P<0.05),与膝关节Lysholm评分、HSS评分值呈负相关(P<0.05)。结论RA患者血清anti-Sa、anti-CCP抗体浓度异常升高,且具体水平与机体炎症反应程度、骨关节损伤程度密切相关,对RA病情严重程度评估具有重要意义。Objective To detect the serum levels of anti-Sa and anti-CCP antibodies in patients with rheumatoid arthritis(RA),explore the relationship with inflammation,bone and joint injury.Methods A total of 129 RA patients first diagnosed and treated in our hospital during January 2014 to May 2018 were selected as RA group,100 healthy volunteers for physical examination were selected as the control group.Serum anti-Sa and anti-CCP antibody levels,serum inflammatory factors,bone and joint injury score and related indicators were measured.Pearson test was used to evaluate the correlation between serum anti-Sa,anti-CCP antibody levels and RA severity.Results Serum anti-Sa and anti-CCP antibody levels in RA group were higher than those in control group(P<0.05).Serum contents of inflammatory factors including TNF-a,IL-17,IL-22 and IL-37 in RA group were higher than those in the control group,Lysholm score and HSS score were lower than those in the control group,and the contents of OPG,RANKL and MMP3 were higher than those in the control group(P<0.05).Correlation analysis showed that serum anti-Sa and anti-CCP antibody levels in RA patients were positively correlated with serum inflammatory factors,bone and joint injury related indicators;but negatively correlated with Lysholm score and HSS score(P<0.05).Conclusion Serum levels of anti-Sa and anti-CCP antibodies in RA patients elevate abnormally,and the specific levels are closely related to the degree of inflammation,bone and joint injury,which have great significance to RA severity assessment.

关 键 词：类风湿性关节炎 抗环状瓜氨酸抗体 抗SA抗体 炎症反应 骨关节损伤 

分 类 号：R593.22[医药卫生—内科学]