在不同系统中血糖、血尿酸、胆固醇检测的比对和偏倚评估  

Comparison and bias evaluation of blood glucose,blood uric acid and cholesterol tests in different detection systems

作　　者：于俊才 华咏艳 曹勤[1] 左安欣 YU Jun-cai;HUA Yong-yan;CAO Qin;ZUO An-xin(Department of Laboratory,the Second Chinese Medicine Hospital of Jiangsu Province,the Second Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210000,China)

机构地区：[1]江苏省第二中医院南京中医药大学第二附属医院检验科

出　　处：《中国临床研究》2020年第2期232-236,共5页Chinese Journal of Clinical Research

摘　　要：目的探讨不同检测系统血糖(Glu)、尿酸(BUA)、胆固醇(CHOL)三项指标测定结果的可比性,以确保实验室应用不同仪器设备检测同一项目时的准确性,并为其结果的一致性提供依据。方法以贝克曼AU-5800全自动生化分析仪检测系统为目标检测系统(比较方法),宣大(SD-1311型)及易立测(ET-301型)便携式检测系统为实验方法。分别测定40例患者Glu、BUA、CHOL水平,计算实验方法与比较方法之间的相对偏倚(SE%),判断不同分析系统的可比性及一致性。结果生化仪的检测精密度良好,结果可靠。宣大检测仪的Glu在低、中、高三个医学决定水平的SE%分别为12. 6%、15. 4%和15. 9%;BUA的SE%为11. 2%、7. 9%和7. 6%;CHOL的SE%为5. 9%、6. 1%和6. 5%。易立测检测仪的Glu在低、中、高三个医学决定水平的SE%分别为10. 7%、9. 4%和9. 1%;BUA的SE%为12. 8%、6. 4%和5. 9%;CHOL的SE%为9. 8%、8. 8%和6. 8%,均低于可接受限范围,提示两种便携式检测仪检测结果与生化仪结果一致。线性相关分析结果显示,在检测三个指标时,三种检测系统两两之间的相关系数均大于0. 975。结论本研究中的Glu、BUA、CHOL在宣大(SD-1311型)、易立测(ET-301型)和AU-5800型生化仪上的检测结果一致,具有可比性。Objective To discuss the comparability of the detection results of blood glucose(Glu),blood uric acid(BUA)and cholesterol(CHOL) in different detection systems to ensure the accuracy of the same item when using different instruments and equipment in the laboratory and provide the basis for the consistency of the results. Methods Beckman AU-5800 automatic biochemical analyzer detection system was served as the target detection for compartive method,and Xuanda(SD-1311) and Yili(ET-301) portable detection system were used for experimental method. The Glu,BUA and CHOL were respectively measured with different detection systems in 40 patients,and the relative bias(SE%) between experimental method and comparative method was calculated to judge the comparability and consistency of different detection systems. Results The biochemical analyzer showed good precision and reliable results. In Xuanda detector,SE%for Glu at levels of low,middle and high medical decision were 12. 6%,15. 4%,and 15. 9%,respectively;SE% of BUA were 11. 2%,7. 9% and 7. 6%,respectively;SE% of CHOL were 5. 9%,6. 1%,6. 5%,respectively. In Yili tester,SE%for Glu at levels of low,middle and high medical decision were 10. 7%,9. 4%,and 9. 1%,respectively;SE% for BUA were 12. 8%,6. 4% and 5. 9%,respectively;SE% for CHOL were 9. 8%,8. 8%,6. 8%,respectively. All of above results were below the acceptable limit,indicating that the test results by two kinds of Portable detectors were consistent with those of biochemical instruments. Linear correlation analysis showed that when detecting abone three indicators,the correlation coefficients between any two of the three detection systems were greater than 0. 975. Conclusion The results of Glu,BUA,and CHOL detected by Xuanda(SD-1311) and Yili(ET-301) are consistent and comparable with the results of the AU-5800 biochemical analyzer.

关 键 词：检测系统 全自动生化分析仪 便携式检测仪 血液生化指标 偏倚评估 

分 类 号：R446.112[医药卫生—诊断学]