病原性曲霉三唑类药物耐药机制的研究进展  

Research Progress on Triazole Resistance Mechanism of Pathogenic Aspergillum

作　　者：周亚彬 王千[1] 李若瑜[1] 刘伟[1] ZHOU Yabin;WANG Qian;LI Ruoyu;LIU Wei(Department of Dermatology&Venereology,Peking University First Hospital,Research Center for Medical Mycology,Beijing Key Laboratory of Molecular Diagnosis on Dermatoses,Peking University,Beijing 100034,China)

机构地区：[1]北京大学第一医院皮肤性病科北京大学真菌与真菌病研究中心皮肤病分子诊断北京市重点实验室

出　　处：《菌物研究》2019年第4期199-206,共8页Journal of Fungal Research

基　　金：国家自然科学基金项目(81671990,81861148028)

摘　　要：近年来随着免疫抑制人群的不断增加,侵袭性曲霉病的发病率不断增高。然而随着三唑类药物在临床上的广泛使用,病原性曲霉对三唑类药物的耐药率逐渐增加,是临床治疗重大挑战。文中综述了病原性曲霉对三唑类药物耐药机制的研究进展。曲霉对三唑类药物的耐药机制主要包括cyp51的突变与过表达、药物外排泵的过表达、应激适应通路的激活、生物膜的形成,以及脂质合成相关基因参与而导致的耐药。With the increasing number of immunosuppressive populations recently,the incidence of invasive aspergillosis is increasing.In the meantime,with the over-use of triazole in the clinic,triazole resistant pathogenic Aspergillus strains are often reported.Triazole resistance in Aspergillus has been a big challenge to clinical treatment.This review summarized research progress on the triazole resistance mechanism of pathogenic Aspergillus.The triazole resistance mechanism of Aspergillus mainly includes mutation and overexpression of cyp51,overexpression of drug efflux pumps,formation of biofilm,activation of stress response pathways and participation of lipid synthesis related genes.

关 键 词：曲霉 三唑类药物 耐药机制 羊毛甾醇14α-去甲基化酶 外排泵 

分 类 号：Q949.32[生物学—植物学] R379[医药卫生—病原生物学]