磁共振扩散加权成像对肝纤维化的诊断价值  

Study on diagnostic value of DWI by magnetic resonance imaging for liver fibrosis

作　　者：邢卫红[1] 刘斋[2] 李若旭[1] 高志梅 XING Weihong;LIU Zhai;LI Ruoxu(Department of Radiology,Shijiazhuang Fifth Hospital,Hebei Province,Shijiazhuang City 050031,China)

机构地区：[1]石家庄市第五医院放射科,050031 [2]河北医科大学第一医院放射科,石家庄市050031

出　　处：《临床合理用药杂志》2019年第35期29-30,23,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的分析磁共振扩散加权成像(DWI)对肝纤维化分期的诊断意义。方法选取经肝脏活检确诊的肝纤维化患者41例和健康正常人12例进行肝脏DWI检查,扩散敏感系数(b)值选取0、800 s/mm2,并获得相应表观扩散系数(ADC)图,在ADC图上选择测量感兴趣区(ROI)进行测量,计算出肝脏ADC值。对肝脏ADC值与肝纤维化分期进行相关分析,并对不同肝纤维化分期之间的肝脏ADC值进行统计分析。结果肝脏ADC值随着肝纤维化分期的升高而减低,肝脏ADC值与纤维化分期呈负相关(r=-0. 41,P <0. 05)。对照组ADC值与肝纤维组各期ADC值之间有统计学差异,肝纤维化各期ADC值中,S1与S4的ADC值差异有统计学意义(P <0. 05)。结论肝脏ADC值与肝纤维化具有相关性,有一定的临床诊断价值。Objective To explore the diagnostic value of diffusion-weighted imaging( DWI) in the detection and staging of liver fibrosis. Methods Diffusion weighted imaging( DWI) was performed with b-factors of 0,800 s/mm2 in 41 patients with liver fibrosis under biopsy,and 12 healthy volunteers. ADC values were obtained by placing regions of interest in four segments of the liver. Differences between the different stage of hepatic fibrosis group( n = 41) and control group( n = 12)ADC values were compared and the differences of different stage of hepatic fibrosis group ADC values were compared. Further,the correlation between liver ADC values of hepatic fibrosis group and staging of hepatic fibrosis were examined. Results Pearson correlation analyses showed lower ADC values were associated with higher fibrosis stage( r =-0. 41,P < 0. 05).There were statistically significant differences in liver ADC values between the ADC value of control group and the ADC value of liver fibrosis( P < 0. 05). Conclusion The ADC value of liver applied to the diagnosis of liver fibrosis in patients has higher clinical value.

关 键 词：肝脏 纤维化 扩散加权成像 表观扩散系数 

分 类 号：R445.2[医药卫生—影像医学与核医学] R575.2[医药卫生—诊断学]