赤芍颗粒调控HBV感染免疫耐受期患者免疫通道的临床研究  

Clinical Study on the Regulation of Immune Channels of Patients with HBV Infection in Immune Tolerance Period by Chishao Granule

作　　者：王雪娟[1] 黄瑞诚[2] 张永琴[1] 官志杰[1] 刘潇[1] 潘哲[1] 潘红霞[1] 黄小丽[1] 唐美莲 

机构地区：[1]广西中医药大学第一附属医院,广西南宁530023 [2]广西中医药大学,广西南宁530001

出　　处：《大众科技》2019年第12期44-46,56,共4页Popular Science & Technology

基　　金：2018年广西高校中青年教师基础能力提升项目(2018KY0277)

摘　　要：目的:探讨赤芍颗粒对DC/IL-12/CTL免疫通道中相关免疫因子的调节、免疫细胞功能的促进作用,明确赤芍颗粒打破HBV免疫耐受的作用机制。方法:选取60例符合纳入标准的HBV感染免疫耐受期患者,按照随机数字法分为治疗组及对照组各30例,治疗组给予赤芍颗粒治疗,对照组给予中药安慰剂治疗。治疗结束后比较两组患者CD80、CD86、HLA-DR、IL-12、CD8+T细胞数及血清HBV-DNA水平变化情况。结果:疗程结束后,治疗组CD80、CD86、HLA-DR、IL-12、CD8+T细胞数及血清HBV-DNA水平均有明显改善,且明显优于对照组,差异具有统计学意义。结论:赤芍颗粒能显著改善HBV感染免疫耐受期患者的免疫指标,抑制HBV-DNA复制,打破CHB免疫耐受,其机制可能与DC/IL-12/CTL免疫通道的激活有关。Objective:To explore the effect of red peony granules on the regulation of related immune factors in DC/il-12/CTL immune channel and the promotion of immune cell function,and to clarify the mechanism of Chishao granule to break HBV immune tolerance and to clarify the mechanism of Chishao granule to break HBV immune tolerance.Methods:60 patients with HBV infection immune tolerance stage that met the inclusion criteria were selected,and were divided into treatment group and control group with 30 cases each according to the random number method.The treatment group was treated with Chishao granule and he control group was treated with traditional Chinese medicine placebo.After treatment,the number of CD80,CD86,HLA-DR,IL-12,CD8 T cells and the level of serum HBV-DNA were compared between the two groups.Results:After the treatment,the number of CD80,CD86,HLA-DR,IL-12,CD8 T cells and the level of serum HBV-DNA in the treatment group were significantly improved.It is obviously superior to the control group.The difference is statistically significant.Conclusion:Chishao granule can significantly improve the immune indexe of patients with HBV infection in immune tolerance period,suppress HBV-DNA replication,and break CHB immune tolerance.The mechanism may be related to the activation of the DC/IL-12/CTL immune channel.

关 键 词：赤芍颗粒 免疫耐受期 临床研究 

分 类 号：R286[医药卫生—中药学]