限时禁食法控制冠心病患者体重和血脂的临床研究  

Time-restricted fasting in controlling body weight and blood fat in patients with coronary heart disease:a clinical randomized study

作　　者：陈智远[1] 魏庆民 刘亚玲 陈如群 黎汝 蔡华[1] Chen Zhiyuan;Wei Qingmin;Liu Yaling;Chen Ruqun;Li Ru;Cai Hua(Department of Hunan Provincial People'Hospital,First Affiliated Hospital of Human Normal University,Changsha 410005,China)

机构地区：[1]湖南省人民医院湖南师范大学附属第一医院,长沙410005 [2]邢台市人民医院河北医科大学附属医院心血管内科,邢台054031

出　　处：《中国循证心血管医学杂志》2020年第2期217-220,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的限时禁食法是一种新的饮食疗法,可减轻体重和改善血脂异常,但对冠状动脉粥样硬化性心脏病(冠心病)患者的影响尚不清楚。本研究旨在探讨限时禁食对冠心病患者体重及血脂的影响。方法通过从我院公告征集冠心病患者154例,随机分为对照组(75例)和限时禁食组(79例),两组均给予12周的饮食干预后,进行人体测量(体重、脂肪量、无脂肪质量)及血脂分析。结果干预4周后,限时禁食组体重较干预前下降[(3.84±0.65)kg(5.16±0.9%)],对照组下降[(2.54±0.34)kg(3.50±0.5%)]。限时禁食组脂肪量较干预前下降[(1.6±0.65)kg(5.38±0.9%)],对照组下降[(1.10±0.34)kg(3.78±0.5%)]。12周后,限时禁食组体重下降[(3.48±0.67)kg(4.77±0.9%)],对照组下降[(2.19±0.65)kg(3.01±0.9%)]。其差异有统计学意义。干预4周后,限时禁食组三酰甘油较干预前下降[(0.64±0.05)mg/dl(23.6±0.9%)],对照组下降[(0.38±0.04)mg/dl(14.1±0.5%)]。12周后,限时禁食组下降[(0.59±0.07)mg/dl(21.8±0.9%)],对照组下降[(0.25±0.06)mg/dl(9.26±0.9%)],两组差异均有统计学意义。结论限时禁食法对冠心病患者是一种安全和可耐受的饮食方案,在较短时间内(4~12周)控制体重和改善血脂异常。限时禁食法对代谢相关疾病的预防作用需进一步研究证实。Objective To discuss the influence of time-restricted fasting on body weight and blood fat in patients with coronary heart disease(CHD).Methods CHD patients(n=154)were collected and divided randomly into control group(n=75)and time-restricted fasting group(n=79).After diet intervention in 2 groups for 12 weeks,the indexes of anthropometric measurements(body weight,fat mass,fat-free mass)and blood fat analysis were conducted.Results After intervention for 4 weeks,the body weight decreased by[(3.84±0.65)kg(5.16±0.9%)]in time-restricted fasting group and by[(2.54±0.34)kg(3.50±0.5%)]in control group.The fat mass decreased by[(1.6±0.65)kg(5.38±0.9%)]in time-restricted fasting group and by[(1.10±0.34)kg(3.78±0.5%)]in control group.After intervention for 12 weeks,the body weight decreased by[(3.48±0.67)kg(4.77±0.9%)]in time-restricted fasting group and by[(2.19±0.65)kg(3.01±0.9%)]in control group.After intervention for 4 weeks,the level of triglyceride(TG)decreased by[(0.64±0.05)mg/dl(23.6±0.9%)]in time-restricted fasting group and by[(0.38±0.04)mg/dl(14.1±0.5%)]in control group.After intervention for 12 weeks,TG level decreased by[(0.59±0.07)mg/dl(21.8±0.9%)]in timerestricted fasting group and by[(0.25±0.06)mg/dl(9.26±0.9%)]in control group.All differences had statistical significance between 2 groups.Conclusion Time-restricted fasting is a safe and tolerable diet plan for CHD patients,which can control body weight and relieve dyslipidaemia within a short term(4 weeks to 12 weeks).The preventive effect of time-restricted fasting on metabolism-related diseases needs to be confirmed by future studies.

关 键 词：限时禁食 冠心病 体重 血脂 

分 类 号：R514.4[医药卫生—内科学]