Systematic Evaluation (Meta-analysis) of the Efficacy and Safety of Pudilan Xiaoyan Oral Liquid (蒲地蓝消炎口服液) in the Treatment of Suppurutive Tonsillitis in Children  

作　　者：DU Ying LV Jian SUN Meng-hua XIE Yan-ming 杜莹;吕健;孙梦华;谢雁鸣(Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences)

机构地区：[1]Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China

出　　处：《World Journal of Integrated Traditional and Western Medicine》2020年第2期26-38,共13页世界中西医结合杂志（英文）

基　　金：National Key Research&Development Plan Project(2018YFC1707400,2018YFC1707410);Research Funding Project For Graduate Education Teaching Reform of China Academy of Chinese Medical Sciences(JG201703)

摘　　要：To systematically evaluate the efficacy and safety of Pudilan Xiaoyan Oral in Liquid(蒲地蓝消炎口服液)in the treatment of suppurative tonsillitis in children.In WanFang,CNKI,VIP,CBM,PubMed,Embase and Corchrane and other databases,relevant literatures about Pudilan Xiaoyan Oral Liquid(蒲地蓝消炎口服液)in the treatment of pediatric suppurative tonsillitis were searched.The retrieval time was from the establishment of the database to April 2019.Relevant randomized controlled trials were extracted.The control group was treated with conventional antibiotics,and the observation group was treated with Pudilan Xiaoyan Oral Liquid(蒲地蓝消炎口服液)based on the control group.After they were summarized and analyzed,Cochrane Handbook 5.1 evaluation standard and RevMan 5.3 software were used to determine the quality of literature.A total of 172 literatures were retrieved and 23 randomized controlled trials were included.A total of 1188 children were in the experimental group while 1175 children were in the control group,involving 2363 children with suppurative tonsillitis.Meta-analysis showed that the total effective rate of Pudilan Xiaoyan Oral Liquid(蒲地蓝消炎口服液)combined with routine treatment was better than that of routine treatment(RR=0.88,95%CI(0.86,0.91),P<0.00001);Pudilan Xiaoyan Oral Liquid(蒲地蓝消炎口服液)combined with routine treatment in children was better than that of routine treatment alone in term of temperature recovery,sore throat time,the reduction of tonsil purulent secretion.There were few reports of adverse reactions and no serious adverse reactions.To sum up,Pudilan Xiaoyan Oral Liquid(蒲地蓝消炎口服液)combined with routine treatment can significantly improve the efficacy of children with suppurative tonsillitis,but due to the low quality of the included literature,it should be used cautiously.It is suggested that clinical randomized controlled trials should be designed with large sample size,multi-centers and conforming to international standards toTo systematically evaluate the efficacy and safety of Pudilan Xiaoyan Oral in Liquid(蒲地蓝消炎口服液) in the treatment of suppurative tonsillitis in children. In WanFang, CNKI, VIP, CBM, PubMed,Embase and Corchrane and other databases, relevant literatures about Pudilan Xiaoyan Oral Liquid(蒲地蓝消炎口服液) in the treatment of pediatric suppurative tonsillitis were searched. The retrieval time was from the establishment of the database to April 2019. Relevant randomized controlled trials were extracted. The control group was treated with conventional antibiotics, and the observation group was treated with Pudilan Xiaoyan Oral Liquid(蒲地蓝消炎口服液) based on the control group. After they were summarized and analyzed, Cochrane Handbook 5.1 evaluation standard and RevMan 5.3 software were used to determine the quality of literature. A total of 172 literatures were retrieved and 23 randomized controlled trials were included. A total of 1188 children were in the experimental group while 1175 children were in the control group, involving 2363 children with suppurative tonsillitis. Meta-analysis showed that the total effective rate of Pudilan Xiaoyan Oral Liquid(蒲地蓝消炎口服液) combined with routine treatment was better than that of routine treatment(RR = 0.88, 95% CI(0.86, 0.91), P<0.00001); Pudilan Xiaoyan Oral Liquid(蒲地蓝消炎口服液) combined with routine treatment in children was better than that of routine treatment alone in term of temperature recovery, sore throat time, the reduction of tonsil purulent secretion. There were few reports of adverse reactions and no serious adverse reactions. To sum up, Pudilan Xiaoyan Oral Liquid(蒲地蓝消炎口服液) combined with routine treatment can significantly improve the efficacy of children with suppurative tonsillitis, but due to the low quality of the included literature, it should be used cautiously. It is suggested that clinical randomized controlled trials should be designed with large sample size, multi-centers and co

关 键 词：PUDILAN TONSILLITIS Randomized controlled trials Systematic evaluation META-ANALYSIS 

分 类 号：R766.18[医药卫生—耳鼻咽喉科]