多西他赛+奥沙利铂化疗联合调强放疗治疗鼻咽癌的影像学疗效评估  

Imaging evaluation of docetaxel plus oxaliplatin chemotherapy combined with intensity modulated radiotherapy for nasopharyngeal carcinoma

作　　者：潘雅[1] 黄家军 黄继红[1] 苏炳泽[1] 王海妹[1] 陈赛明 王晓凤[1] Pan Ya;Huang Jiajun;Huang Jihong;Su Bingze;Wang Haimei;Chen Saiming;Wang Xiaofeng(Department of ENT,the First Affiliated Hospital of Hainan Medical University,Hainan Haikou 570102,China)

机构地区：[1]海南医学院第一附属医院耳鼻喉科

出　　处：《现代肿瘤医学》2020年第6期922-926,共5页Journal of Modern Oncology

摘　　要：目的:探讨与评估多西他赛+奥沙利铂化疗联合调强放疗治疗鼻咽癌的影像学疗效。方法:2011年8月到2015年5月选择在我院诊治的鼻咽癌患者160例作为研究对象,根据信封法随机平分为观察组与对照组各80例,对照组给予调强放疗治疗,观察组在对照组治疗的基础上给予多西他赛+奥沙利铂化疗,两组都治疗并观察患者4个周期。结果:在客观缓解率方面,观察组达到75.0%,而对照组是57.5%,观察组较对照组明显要高(P<0.05)。观察组与对照组治疗期间的血象异常、肝肾功能异常、消化道反应等毒副反应发生情况对比无明显差异(P>0.05)。治疗后观察组与对照组的血清CEA水平分别为(9.99±6.30)ng/ml和(14.29±8.14)ng/ml,都明显低于治疗前的(27.83±11.93)ng/ml和(27.81±10.82)ng/ml,观察组治疗后的血清CEA水平也明显低于对照组(P<0.05)。随访发现,观察组患者中位生存时间是(19.33±2.78)个月,对照组是(14.98±3.14)个月,观察组较对照组明显要长(t=6.482,P<0.05)。结论:多西他赛+奥沙利铂化疗联合调强放疗治疗鼻咽癌能提高患者的影像学评估效果,促进血清肿瘤标志物表达下降,不会增加毒副反应的发生,从而延长患者的生存时间。Objective:To evaluate the imaging efficacy of docetaxel plus oxaliplatin chemotherapy combined with intensity modulated radiotherapy in the treatment of nasopharyngeal carcinoma.Methods:From August 2011 to May 2015,160 cases of nasopharyngeal carcinoma patients in our hospital were selected as the research object.All the cases were divided into observation group and control group with 80 cases in each group.The control group was given intensity modulated radiotherapy,and the observation group was given docetaxel+oxaliplatin chemotherapy based on the treatment in control group.Two groups were treated for 4 cycles.Results:The objective response rate of the observation group was 75.0%,and 57.5%in the control group.The observation group was significantly higher than that of the control group(P<0.05).There were no significant differences between the observation group and the control group during the treatment of abnormal blood picture,abnormal liver and kidney function,gastrointestinal reaction and other side effects(P>0.05).After treatment,the serum CEA of observation group and control group were(14.29±8.14)ng/ml and(9.99±6.30)ng/ml that were significantly longer than before treatment of the(27.83±11.93)ng/ml and(27.81±10.82)ng/ml,and the observation group after treatment was significantly lower than the control group(P<0.05).Up to now,the median survival time of the observation group and the control group were(19.33±2.78)months and(14.98±3.14)months,and the median survival time of the observation group was significantly higher than that of the control group(P<0.05).Conclusion:Docetaxel plus oxaliplatin chemotherapy combined with intensity modulated radiotherapy for nasopharyngeal carcinoma can improve the imaging effects,it also can promote the serum tumor marker expression decreased and not increase toxicities,and prolong the survival time of patients.

关 键 词：鼻咽癌 多西他赛 奥沙利铂 调强放疗 影像学疗效评估 

分 类 号：R739.6[医药卫生—肿瘤]