舒肝益肾方联合内分泌治疗激素依赖型乳腺癌患者的临床效果  

Clinical Study on Shugan Yishen Decoction Combined with Endocrine Therapy for Hormone-Dependent Breast Cancer

作　　者：王晓玲[1] 郑艺[1] 李江涛[1] WANG Xiaoling;ZHENG Yi;LI Jiangtao(Department of Oncology,Qinhuangdao Chinese Medicine Hospital,Qinhuangdao 066000,China)

机构地区：[1]河北省秦皇岛市中医医院肿瘤科,秦皇岛066000

出　　处：《世界中医药》2020年第3期416-420,共5页World Chinese Medicine

基　　金：2016年度河北省医学科学研究重点课题计划项目(20160590)。

摘　　要：目的:探究舒肝益肾方联合内分泌对激素依赖型乳腺癌疗效,以期丰富治疗方法,提高疗效。方法:选取2014年1月至2018年12月秦皇岛市中医医院收治的激素依赖型乳腺癌患者94例作为研究对象,按照就诊顺序编号随机分为对照组和观察组,每组47例。对照组常规内分泌治疗,观察组在对照组基础上加用舒肝益肾方治疗,同时治疗4周。观察2组治疗前、治疗后肿瘤标志物、免疫功能、肝功能、凝血功能、生命质量、中医证候积分变化并比较。结果:治疗后2组癌抗原153(CA153)、糖链型抗原125(CA125)较治疗前显著下降,差异有统计学意义(P<0.05),治疗后观察组以上指标显著低于对照组,差异有统计学意义(P<0.05)。治疗后观察组CD3^+、CD4^+、CD4^+/CD8^+、自然杀伤细胞(NK)、IgA、IgG、IgM较治疗前显著升高,CD8^+则显著下降,差异有统计学意义(P<0.05),对照组治疗前、治疗后比较,差异无统计学意义(P>0.05),治疗后观察组CD8^+显著低于对照组,余均显著高于对照组,差异有统计学意义(P<0.05)。治疗后对照组总胆固醇(TC)、谷氨酰转肽酶(GCT)、纤维蛋白原(FIB)、部分凝血酶时间(APTT)较治疗前显著上升,差异有统计学意义(P<0.05),观察组治疗后和治疗前比较,差异无统计学意义(P>0.05),治疗后观察组以上指标显著低于对照组,差异有统计学意义(P<0.05)。治疗后2组躯体功能、角色功能、情绪功能、认知功能、社会功能、整体生命质量较治疗前显著升高,差异有统计学意义(P<0.05),治疗后观察组以上指标显著高于对照组,差异有统计学意义(P<0.05)。治疗后2组情志抑郁、不寐、心烦易怒、腰膝酸软、肢体受限较治疗前显著下降,差异有统计学意义(P<0.05),治疗后观察组以上指标显著低于对照组,差异有统计学意义(P<0.05)。结论:舒肝益肾方联合内分泌能提高激素依赖型乳腺癌免疫功能,抑制肿瘤进展,从而改善临床症Objective:To explore the therapeutic effects of Shugan Yishen Decoction combined with endocrine on hormone-dependent breast cancer,in order to enrich the treatment methods and improve the curative effect.Methods:A total of 94 patients with hormone-dependent breast cancer hospitalized in Qinhuangdao Chinese Medicine Hospital from January 2014 to December 2018 were randomly divided into a control group(47 cases)and an observation group(47 cases).The control group received routine endocrine therapy,while the observation group received Shugan Yishen Decoction on the basis of the control group for 4 weeks.The changes of tumor markers,immune function,liver function,blood coagulation function,quality of life and TCM syndrome scores before and after treatment were observed and compared between the 2 groups.Results:1)After treatment,CA125 and CA153 in the 2 groups were significantly decreased than those before treatment(P<0.05),and the above indexes in the observation group were significantly lower than those in the control group(P<0.05).2)After treatment,CD3^+,CD4^+,CD4^+/CD8^+,NK,IgA,IgG and IgM in the observation group increased significantly,while CD8^+decreased significantly(P<0.05).There was no significant difference between the control group before and after treatment(P>0.05).After treatment,CD8^+in the observation group was significantly lower than that in the control group,and the rest was significantly higher than that in the control group(P<0.05).3)After treatment,total cholesterol(TC),glutamyl transpeptidase(GCT),fibrinogen(FIB),and partial thrombin time(APTT)in the control group were significantly increased than those before treatment(P<0.05).There was no significant difference between the observation group after treatment and before treatment(P>0.05),and the above indexes in the observation group after treatment were significantly lower than those in the control group(P<0.05).4)After treatment,the physical function,role function,emotional function,cognitive function,social function and overall quality of lif

关 键 词：舒肝益肾方 内分泌 激素依赖型乳腺癌 肿瘤标志物 免疫功能 肝功能 生命质量 中医证候积分 

分 类 号：R289.5[医药卫生—方剂学] R730.3[医药卫生—中药学]