血小板与糖尿病及糖尿病肾病相关性研究进展  

Advances in the study of the relationship between platelet and diabetes and diabetic nephropathy

作　　者：蔡劲薇[1] 罗艳霞(综述)[1] 邝建(审校) CAI Jin-wei;LUO Yan-xia;KUANG Jian(Department of Endocrinology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学第一附属医院内分泌科,南宁530021 [2]广东省人民医院,广东省医学科学院,广东省老年医学研究所内分泌科,广州510080

出　　处：《中国临床新医学》2020年第2期195-199,共5页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：国家重点研发计划项目(编号:2018YFC1314104);广西自然科学基金项目(编号:2017GXNSFAA198097)

摘　　要：持续高血糖可导致肾脏微脉管系统的中断,渐进性损伤肾小球毛细血管和小管间质,也可以诱发血小板(platelet,PLT)的高凝状态。PLT通过改变形态、功能以及活化状态在糖尿病(diabetes mellitus,DM)及血管并发症中扮演重要的角色。该文对PLT与DM及糖尿病肾病(diabetic nephropathy,DN)的相关性研究进展进行综述。Hyperglycemia can lead to the interruption of renal microvascular system,progressive damage of glomerular capillary and tubulointerstitial,and also induce the hypercoagulability of platelet(PLT).PLT plays an important role in diabetes mellitus(DM)and vascular complications by changing its morphology,function and activation state.The correlation between PLT and DM and diabetic nephropathy(DN)is reviewed in this paper.

关 键 词：血小板 糖尿病 糖尿病肾病 

分 类 号：R58[医药卫生—内分泌]