二甲双胍联用枸橼酸氯米芬柠檬酸盐不同疗程诱导PCOS排卵效果  

Effect of different courses of metformin combined with clomiphene citrate for ovulation induction of women with polycystic ovary syndrome

作　　者：蒯晓莉 蓝传泰 江慧英[1] KUAI XiaoLi;LAN Chuantai;JIANG Huiying(Taishun People's Hospital,Zhejiang Province,325500)

机构地区：[1]浙江省泰顺县人民医院

出　　处：《中国计划生育学杂志》2020年第2期176-179,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨不同疗程二甲双胍联用枸橼酸氯米芬柠檬酸盐(CC)治疗PCOS妇女促排卵效果。方法:选取2016年1月-2017年12月本院收治的合并胰岛素抵抗与CC抵抗PCOS患者103例,随机分为长疗程组(12周,34例),短疗程组(4周,35例)及超短疗程组(14d,34例)。观测不同组别患者治疗后卵泡、子宫内膜发育,宫颈粘液评分、性激素水平,连续观测治疗后6个月经周期,统计妊娠结局。结果:治疗后长疗程组及短疗程组成熟卵泡个数、宫颈粘液评分均高于超短疗程组,子宫内膜厚度高于超短疗程组(P<0.05)。长疗程组排卵率(91.2%)最高,短疗程组妊娠率最高(53.4%)。3组血清及卵泡雌二醇、三线症阳性比例无差异(P>0.05)。结论:二甲双胍与枸橼酸氯米芬短疗程联用可有效保障合并胰岛素抵抗与CC抵抗的PCOS患者促排卵效果,同时缩短治疗周期,可在临床上探索应用。Objective:To explore the effect of different courses of metformin combined with clomiphene citrate(CC)for ovulation induction of women with polycystic ovary syndrome(PCOS).Methods:Women with PCOS were selected as subjects,and were randomly devided in group A,B,and C from January 2016 to December 2017.34 women in group A were treated by metformin combined with CC for 12 weeks(long course),35 women in group B were treated by metformin combined with CC for 4 weeks(short course),and 34 women in group C were treated by metformin combined with CC for 14d(ultra-short course).After six menstrual cycles followed up,the follicular development,endometrial development,cervical mucus score,and sex hormones levels of women in the three groups were observed,and the pregnancy outcomes of all women were calculated.Results:The number of mature follicles,cervical mucus score,and the endometrium thickness of women in group A and B were significant higher than those of women in group C(P<0.05).The ovulation rate(91.2%)of women in group A was highest,and the pregnancy rate(54.3%)of women in group C was highest.There were no statistical significant different in levels of serum and follicular E 2,and the rate of third line markers of endometrium morphology by ultrasound of women among the three groups(P>0.05).Conclusion:The short course of metformin combined with CC can effectively promote the ovulation induction effect of PCOS women with insulin resistance and CC resistance,and can shorten the treatment period,which can be application in clinical practice.

关 键 词：多囊卵巢综合征 诱导排卵:二甲双胍 枸橼酸氯米芬 不同疗程 

分 类 号：R711.75[医药卫生—妇产科学]