妇科千金胶囊辅助孕三烯酮对子宫内膜异位症患者性激素和血管新生因子的影响  

Effect of fuke qianjin capsule combined with gestrinone for treating women with endometriosis on their sex hormones levels and angiogenic factors

作　　者：苏惠文 黄浩[1] 李新红 文仲勇[1] 林静霞 SU Huiwen;HUANG Hao;LI Xinhong;WEN Zhongyong;LIN Jingxia(Nanhai District People's Hospital of Foshan City,Guangdong Province,28200)

机构地区：[1]广东省佛山市南海区人民医院

出　　处：《中国计划生育学杂志》2020年第2期180-183,188,共5页Chinese Journal of Family Planning

摘　　要：目的:观察妇科千金胶囊辅助孕三烯酮治疗子宫内膜异位症疗效及对患者炎性因子、性激素和血管新生因子水平的影响。方法:选取2016年12月-2018年8月本院治疗的子宫内膜异位症患者85例,随机分为对照组和观察组,对照组40例给予单纯孕三烯酮治疗,观察组45例在对照组治疗基础上给予妇科千金胶囊治疗。观察临床疗效及治疗前后炎性因子、性激素、血管新生指标的变化和不良反应。结果:治疗后总有效率观察组(95.6%)高于对照组(77.5%)(P<0.05),不良反应发生率两组(12.5%、8.9%)无差异(P>0.05);白细胞介素(IL-6、IL-8)、肿瘤坏死因子(TNF-α)、血管新生因子(VEGF)、瘦素(Leptin)两组均下降,且观察组下降程度优于对照组(P<0.05);性激素(FSH、LH、E 2)水平观察组低于对照组和治疗前(P<0.05),抗苗勒氏管激素(AMH)水平高于对照组和治疗前(P<0.05)。结论:妇科千金胶囊辅助孕三烯酮对子宫内膜异位症可提高疗效,抑制炎症反应和血管新生因子水平,更好改善患者性激素水平,未增加药物不良反应发生。Objective:To observe the effect of fuke qianjin capsule combined with gestrinone for treating women with endometriosis on their sex hormones levels and angiogenic factors.Methods:85 women with endometriosis were randomly divided into control group and observation group from December 2016 to August 2018,40 women in the control group were treated by gestrinone alone,and 45 patients in the observation group were treated by fuke qianjin capsule combined with gestrinone.The clinical efficacy,the changes of inflammatory factors,sex hormones levels,and angiogenesis indicators after treatment,and the rate of adverse reaction of women in the two groups were observed.Results:After treatment,the total effective rate of women in the observation group was 95.6%,which was significant higher than that(77.50%)of women in the control group(P<0.05).The incidence of adverse reaction of women in the observation group was 12.5%,which had no significant different to that(8.9%)of women in the control group(P>0.05).After treatment,the levels of IL-6,IL-8,TNF-α,s-CRP,VEGF,and leptin of women in the two groups had decreased significantly,and which of women in the observation group were significant lower than those of women in the control group(P<0.05).The levels of FSH,LH and E 2 of women in the observation group had decreased significantly after treatment,and which were also significant lower than those of women in the control group(P<0.05).The AMH level of women in the observation group had increased significantly after treatment,and which was also significant higher than that of women in the control group(P<0.05).Conclusion:Fuke qianjin capsule combined with gestrinone for treating women with endometriosis can reduce the inflammatory reaction and angiogenic factors significantly,and have positive effect on the levels of sex hormones,but don’t increase adverse reaction.

关 键 词：子宫内膜异位症 妇科千金胶囊 孕三烯酮 性激素 血管新生因子 炎性因子 

分 类 号：R711.71[医药卫生—妇产科学]