地屈孕酮联合黄体酮胶丸治疗黄体功能不全先兆流产效果  

Effect of dydrogesterone combined with progesterone capsules for treating women with threatened abortion because of corpus luteum dysfunction

作　　者：杨延凤 杨旸 YANG Yanfeng;YANG Xing(The Fourth people's Hospital of Kunshan,Jiangsu province,215300)

机构地区：[1]江苏省昆山第四人民医院

出　　处：《中国计划生育学杂志》2020年第2期223-225,共3页Chinese Journal of Family Planning

摘　　要：目的:探讨地屈孕酮联合黄体酮胶丸治疗黄体功能不全先兆流产保胎效果。方法:选取本院收治的80例黄体功能不全先兆流产患者,随机数字表法分为两组(n=40),对照组地屈孕酮片联合肌注黄体酮,观察组地屈孕酮联合口服黄体酮胶丸。对比两组治疗效果及不良反应发生率等。结果:治疗后两组症状缓解时间及消失时间无差异(P>0.05)。与治疗前相比,两组治疗后血清孕酮(P)、雌二醇(E 2)、绒毛膜促性腺激素(β-hCG)水平均升高(P<0.05),但两组无差异(P>0.05)。观察组保胎成功率(97.5%)与对照组(95.0%)无差异(P<0.05),治疗期间不良反应总发生率(5.0%)低于对照组(25.0%)(P<0.05)。结论:地屈孕酮联合黄体酮胶丸治疗黄体功能不全先兆流产能够迅速地缓解临床症状,提高孕激素水平,提高保胎成功率,其疗效与地屈孕酮联合肌注黄体酮相当,但不良反应更小,安全性更好,且给药方便。Objective:To investigate the effect of dydrogesterone combined with progesterone capsules for treating women with threatened abortion because of corpus luteum dysfunction.Methods:80 women with threatened abortion because of corpus luteum dysfunction were enrolled as study objects,and they were randomly divided into two groups(40 cases in each group)by random numbers table.The women in the control group were treated with dydrogesterone tablets and intramuscular progesterone,and the women in the research group were treated with dydrogesterone and progesterone capsules.The efficacy and adverse reaction of women were compared between the two groups.Results:There were no significant different in the time of symptom relief and symptom disappearance of women after treatment between the two groups(P>0.05).After treatment,the levels of serum P,E 2,andβ-hCG of women in the two groups had increased significantly(P<0.05),but there were no significant different in the levels of serum P,E 2,andβ-hCG of women between the two groups(P>0.05).The success rate of spuc of women in the research group was 97.5%,which had no different to that(95.0%)of women in the control group(P>0.05).The overall incidence of adverse reactions of women in the research group was 5.0%,which was significant lower than that(25.0%)of women in the control group(P<0.05).Conclusion:Dydrogesterone combined with progesterone capsules for treating women with threatened abortion because of luteal insufficiency can quickly relieve clinical symptoms,improve progesterone level,and improve the success rate of spuc.Which’s curative effect is similar to that of dydrogesterone combined with intramuscular injection of progesterone,but the adverse reaction is less,the safety is better,and the administration is convenient.

关 键 词：先兆流产 黄体功能不全 地屈孕酮 黄体酮胶丸 

分 类 号：R714.21[医药卫生—妇产科学]