辽宁省2015年健康人群脊髓灰质炎抗体水平监测分析  

Analysis on polio antibodies among healthy people in liaoning province in 2015

作　　者：任丽萍[1] 邵玉平 王艳[1] 方兴[1] 韩悦[1] 姚文清[1] REN Li-ping;SHAO Yu-ping;WANG Yan;FANG Xing;HAN Yue;YAO Wen-qing(Liaoning Provincial Center for Disease Control and Prevention,Shenyang,Liaoning,110005,China)

机构地区：[1]辽宁省疾病预防控制中心免疫规划所

出　　处：《中国冶金工业医学杂志》2020年第1期1-2,共2页Chinese Medical Journal of Metallurgical industry

基　　金：国家科技重大专项(No.2017ZX10103007-001)

摘　　要：目的了解辽宁省健康人群脊髓灰质炎(脊灰)中和抗体水平,评价脊灰疫苗免疫效果,为维持无脊灰状态提供科学依据。方法采集不同年龄段的健康人群血清,用微量中和法进行中和抗体测定。结果脊灰Ⅰ、Ⅱ、Ⅲ型抗体阳性率分别为98.58%、98.34%、95.73%;几何平均滴度(GMT)分别为:1︰259、1︰104、1︰88。不同年龄组健康人群脊灰抗体GMT差异有统计学意义(P<0.05),抗体水平总体趋势随年龄增长而下降。结论辽宁省健康人群有较高的脊灰免疫水平,已形成有效的免疫保护屏障。Objective To understand the level of Poliomyelitis Antibody among healthy people in Liaoning Province and evaluate the quality of Poliomyelitis vaccine and its effect. Methods Blood serum in different ages among healthy people was collected and neutralizing antibodies were tested with neutralization method for determination. Results The positive rates of polio I, II and III neutralizing antibodies were 98.58% 、98.34% and95.73%;and the geometric mean antibody titers(GMT)were 1∶259、1∶104、1∶88 respectively. The GMT of polio antibody in healthy people in different age groups was statistically significant(P<0.05), which was decreased with the age increasing. Conclusion The polio antibody are maintained a highlevel in Liaoning, and an effective immune protection barrier has formed.

关 键 词：脊髓灰质炎 中和抗体 几何平均滴度(GMT) 

分 类 号：R186[医药卫生—流行病学]