C-反应蛋白在突发性耳聋患者中的临床意义分析  

Analysis of clinical significance of C-reactive protein in patients with sudden deafness

作　　者：赵睿[1] 吴欣华[1] 杨秀海[1] 倪茂美[1] Zhao Rui;Wu Xinhua;Yang Xiuhai;Ni Maomei(Department of Otorhinolaryngology Head and Neck Surgery,Guizhou Provincial People’s Hospital,Guiyang 550002,Guizhou,China)

机构地区：[1]贵州省人民医院耳鼻咽喉头颈外科

出　　处：《贵州医药》2020年第1期13-16,共4页Guizhou Medical Journal

基　　金：贵州省人民医院青年基金(合同编号:GZSYQN[2016]02号)

摘　　要：目的探讨C-反应蛋白(CRP)、C-反应蛋白/白蛋白(CRP/Alb)、中性粒细胞/淋巴细胞(NLR)在突发性耳聋患者的临床意义。方法回顾性分析了98例突发性耳聋患者(治疗组)和90例健康体检者(对照组)。所有患者初诊时行纯音听阈检查,并在治疗结束后复查。根据治疗效果,将治疗组患者分为两组(有效组和无效组),计算C-反应蛋白、CRP/Alb和NLR值,并作组间比较。结果治疗组包括男64例,女34例,平均年龄(45.0±13.2)岁。对照组男50例,女40例,平均年龄(42.1±10.1)。治疗组中CRP(35.31±10.33)mg/L,对照组(3.31±2.33)mg/L,差异有统计学意义(P=0.001)。治疗组CRP/Alb(0.94±0.11),对照组(0.73±0.20),差异有统计学意义(P=0.012);治疗组NLR(2.70±1.11),对照组(1.32±1.01),差异有统计学意义(P=0.033)。治疗组中有效组(包括痊愈、显效和有效)65例,无效组33例;有效组CRP/Alb(0.82±0.13),无效组(1.0±0.72),差异无统计学意义(P=0.318);有效组NLR(2.92±2.00),无效组(4.87±3.53),差异有统计学意义(P=0.005)。结论CRP、CRP/Alb可作为突发性耳聋的辅助诊断,但不能作为预后预测,而NLR则可以作为突发性耳聋的预后预测。Objective To investigate the clinical significance of C-reactive protein(CRP),c-reactive protein/albumin(CRP/Alb)and neutrophil/lymphocyte(NLR)in patients with sudden sensorineural hearing loss.Methods 98 patients with sudden sensorineural hearing loss in treatment group and 90 healthy subjects in control group were retrospectively analyzed.All patients underwent pure tone threshold examination at the initial diagnosis and reexamination at the end of treatment.According to the treatment effect,patients in the treatment group were divided into two groups which were effective group and ineffective group.C-reactive protein,CRP/Alb and NLR values were calculated and compared between groups.Results The treatment group included 34 males and 64 females,with an average age of(45.0±13.2)years.The control group included 50 males and 40 females,with an average age of(42.1±10.1).The CRP of the treatment group was(35.31±10.33)mg/L,and the control group was(3.31±2.33)mg/L.The comparison between the two groups there were statistical significantly differences(P=0.001).CRP/Alb in the treatment group was(0.94±0.11),while that in the control group was(0.73±0.20)and there were statistical significantly differences between the two groups(P=0.012).NLR(2.70±1.11)in the treatment group and(1.32±1.01)in the control group,the comparison between the two groups there were statistical significantly differences(P=0.033).Among which 65 cases(66.3%)were effective(including recovery,significant effect and effective effect),33 cases(33.7%)were ineffective,CRP/Alb(0.82±0.13)in the effective group,and(1.0±0.72)in the ineffective group.The comparison between the two groups there were no statistical significantly differences(P=0.318).NLR of the effective group was(2.92±2.00),while that of the ineffective group was(4.87±3.33).There were statistical significantly differences between the two groups(P=0.005).Conclusion CRP and CRP/Alb in patients with sudden deafness may be assistance in diagnosis,but not predict prognosis.NLA may predict pro

关 键 词：突发性聋 C-反应蛋白 C-反应蛋白/白蛋白 中性粒细胞/淋巴细胞 

分 类 号：R764[医药卫生—耳鼻咽喉科]