脑-肠肽对血糖影响的研究进展  

Update of brain-gut peptides on blood glucose

作　　者：张荧钗 郑仁东[1] 刘超[1] Zhang Yingchai;Zheng Rendong;Liu Chao(Department of Endocrinology and Metabolism,Affiliated Hospital of Integration of Chinese and Western Medicine in Jiangsu Province,Nanjing 210028,China;Nanjing University of Traditional Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学附属中西医结合医院内分泌科,210028 [2]南京中医药大学,210023

出　　处：《国际内分泌代谢杂志》2020年第1期49-51,62,共4页International Journal of Endocrinology and Metabolism

基　　金：江苏省卫生计生委干部保健课题项目(BJ17029)。

摘　　要：人体的神经系统和胃肠道均能够分泌一些激素,如胆囊收缩素、胃泌素和促胰液素等,属于脑-肠肽的范畴。其活动受胃肠道和神经系统双重调节,对机体胃肠运动、食物摄取、能量消耗和物质代谢等有重要影响。脑-肠肽通过延缓胃排空,减少食欲,增加胰岛β细胞量,提高胰高血糖素样肽-1水平等多种途径作用改善血糖水平。Kinds of hormones are existed in nerve system and gastrointestinal tract,such as cholecystokinin,gastrin and secretin,all of which lie in the brain-gut peptides spectrum.Hormones mentioned above are modulated by the bilateral regulation of gastrointestinal and nerve system,which exert a vital role on gastrointestinal motility,food intake,energy consuming and substance metabolism.Brain-gut peptides could improve blood glucose by delaying gastric empty,decreasing appetite,improving β cell mass and enhancing glucagon like peptide-1.

关 键 词：脑-肠肽 血糖 胆囊收缩素 胃泌素 促胰液素 

分 类 号：R587[医药卫生—内分泌]