同型半胱氨酸与恶性肿瘤及中医证型的相关性研究  

Correlation Between Homocysteine and Malignant Tumor and TCM Syndrome

作　　者：沈骁胤 高宏[2] 李夏平[2] SHEN Xiaoyin;GAO Hong;LI Xiaping(Liaoning University of Traditional Chinese Medicine,Liaoning Shenyang 110032,China;The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Liaoning Shenyang 110032,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110032 [2]辽宁中医药大学附属医院肿瘤科,辽宁沈阳110032

出　　处：《中医药临床杂志》2020年第1期73-77,共5页Clinical Journal of Traditional Chinese Medicine

摘　　要：目的:分析129例恶性肿瘤患者血浆同型半胱氨酸水平与多种恶性肿瘤之间的关系,探讨同型半胱氨酸与恶性肿瘤不同中医证型的关系。方法:采用回顾性研究,将符合标准的129例恶性肿瘤患者血浆同型半胱氨酸水平,与45例健康人群对照;根据129例恶性肿瘤患者的四诊信息,进行k-means聚类分析。结果:肺癌组、妇科恶性肿瘤组、乳腺癌组、消化道恶性肿瘤组相较于对照组均显著增高,具有统计学差异;消化道恶性肿瘤组与其余各恶性肿瘤组进行比较,具有统计学差异;129例恶性肿瘤患者的证型可分为脾气亏虚证、痰湿内阻证、肝郁气滞证及肝肾阴虚证,与正常Hcy的参考范围相比较,同型半胱氨酸水平均高于正常范围,且依次升高。肝肾阴虚证、肝郁气滞证分别与其他证型比较,在统计学上存在差异。结论:血浆同型半胱氨酸的高水平表达对于恶性肿瘤患者来说,具有辅助临床诊断的价值,特别是在胃癌、结直肠癌等消化道恶性肿瘤患者中,其相关性更高。中医上,血浆Hcy水平的上升,预示着恶性肿瘤患者疾病的进展,临床上可以通过患者血浆Hcy水平的变化,判断患者病情的变化及预后。肝郁气滞证、肝肾阴虚证是同型半胱氨酸升高的恶性肿瘤患者的病理基础,对中医治疗存在指导价值。Objective:The relationship between plasma homocysteine levels of 129 patients with malignant tumors and various malignant tumors was analyzed,and the relationship between homocysteine and different TCM syndrome types of malignant tumors was analyzed.Methods:A retrospective study was performed to compare plasma homocysteine levels of 129 patients with malignant tumors that met the criteria with 45 healthy people.K-means clustering analysis was performed based on the four diagnostic information of 129 patients with malignant tumors.Results:The lung cancer group,gynecological malignant tumor group,breast cancer group,and gastrointestinal malignant tumor group were significantly higher than the control group,with statistical differences.The gastrointestinal malignant tumor group was compared with the rest of the malignant tumor groups with statistical significance.Differences;the syndrome types of 129 patients with malignant tumors can be divided into spleen deficiency syndrome,internal phlegm dampness syndrome,liver depression and qi stagnation syndrome and liver and kidney yin deficiency syndrome.Compared with the reference range of normal Hcy,homocysteine The water level is higher than the normal range,and it rises in order.Liver-kidney yin deficiency syndrome and liver stagnation Qi stagnation syndrome are statistically different from other syndrome types,respectively.Conclusion:The high level expression of plasma homocysteine is valuable for clinical diagnosis in patients with malignant tumors,especially in patients with gastrointestinal malignant tumors such as gastric cancer and colorectal cancer.In traditional Chinese medicine,an increase in plasma Hcy levels indicates the progression of disease in patients with malignant tumors.Clinically,the changes in the patient’s plasma Hcy levels can be used to judge the patient’s condition and prognosis.The syndrome of liver stagnation and qi stagnation and liver and kidney yin deficiency are the pathological basis of patients with malignant tumors with elevated ho

关 键 词：恶性肿瘤 同型半胱氨酸 中医证型 

分 类 号：R273[医药卫生—中西医结合]