加减石韦散对输尿管镜钬激光碎石术后患者肾功能及炎症指标的影响  

Modified Shiwei Powder has Effect on Renal Function and Inflammatory Indexes of Patients after Ureteroscopic Holmium Laser Lithotripsy

作　　者：叶伟峰 邵法明[2] 吴立武 YE Weifeng;SHAO Faming;WU Liwu

机构地区：[1]象山县红十字台胞医院,浙江象山315700 [2]宁波大学医学院附属医院,浙江宁波315000

出　　处：《新中医》2020年第2期47-49,共3页New Chinese Medicine

摘　　要：目的:观察加减石韦散对输尿管镜钬激光碎石术患者肾功能及炎症指标的影响。方法:选取行输尿管镜钬激光碎石术治疗的输尿管上段结石患者110例,按随机数字表法分为治疗组和对照组各55例。2组均采用输尿管镜钬激光碎石术治疗,治疗组术后给予加减石韦散辅助治疗。记录2组术后结石残留率,观察肾功能及炎症指标的变化。结果:术后30天,治疗组结石残留率1.82%,低于对照组的12.73%(P<0.05)。术后30天,2组尿素氮(BUN)和血肌酐(SCr)水平均较术后24 h降低,且治疗组BUN水平低于对照组,差异均有统计学意义(P<0.05)。术后30天,2组C-反应蛋白(CRP)、降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)水平及治疗组白细胞介素-6(IL-6)水平均较术后24 h下降(P<0.05);治疗组4项炎症指标水平均低于对照组(P<0.05)。结论:加减石韦散辅助输尿管镜钬激光碎石术治疗输尿管上段结石疗效满意,可改善患者的肾功能,减轻术后炎症反应。Objective:To observe the effect of modified Shiwei powder on renal function and inflammatory indexes of patients after ureteroscopic holmium laser lithotripsy.Methods:Selected 110 cases of patients with upper ureteric calculi treated with ureteroscopic holmium laser lithotripsy,divided them into the treatment group and the control group according to the random number table,with 55 cases in each group.Both groups were treated with ureteroscopic holmium laser lithotripsy and the treatment group was additionally given the adjuvant treatment of modified Shiwei powder after operation.Recorded the postoperative rate of residual stone in the two groups and observed the changes of renal function and inflammatory indexes.Results:On the 30th day after surgery,the rate of residual stone in the treatment group was 1.82%,being lower than that of 12.73%in the control group(P<0.05).On the 30th day after surgery,the levels of blood urea nitrogen(BUN)and serum creatinine(SCr)in the two groups were decreased when compared with those at 24 h after surgery,and the levels of BUN in the treatment group were lower than those in the control group,differences being significant(P<0.05).On the 30th day after surgery,the levels of C-reactive protein(CRP),procalcitonin(PCT)and tumor necrosis factor-α(TNF-α)in the two groups and the levels of interleukin-6(IL-6)in the treatment group were all decreased when compared with those at 24 h after the operation,differences being significant(P<0.05);the levels of four inflammatory indexes in the treatment group were all lower than those in the control group,differences being significant(P<0.05).Conclusion:The application of modified Shiwei powder assisted ureteroscopic holmium laser lithotripsy for upper ureteric calculi has satisfactory curative effect,which can improve the renal function of patients and relieve the postoperative inflammatory reactions.

关 键 词：输尿管上段结石 输尿管镜钬激光碎石术 石韦散 肾功能 炎症指标 

分 类 号：R693.4[医药卫生—泌尿科学]