线粒体超微结构及其调控机制的研究进展  

Advances in Mitochondrial Ultrastructure and Its Regulatory Mechanism

作　　者：黄国敏 王玉佩[5] 孙超 张雪甜 张红[1,2,3,4] HUANG Guo-Min;WANG Yu-Pei;SUN Chao;ZHANG Xue-Tian;ZHANG Hong(Institute of Modern Physics,University of Chinese Academy of Sciences,Lanzhou!30000,China;University of Chinese Academy of Sciences,100049,China;Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences,Lanzhoul 30000,China;Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province,Lanzhoul 30000,China;.Gansu Provincial Maternal and Child Health Care Center,Lanzhou!30000,China)

机构地区：[1]中国科学院大学近代物理研究所,兰州730000 [2]中国科学院大学,北京100049 [3]中国科学院重离子束辐射生物医学重点实验室,兰州730000 [4]甘肃省重离子辐射医学重点实验室,兰州730000 [5]甘肃省妇幼保健院,兰州730000

出　　处：《生物化学与生物物理进展》2019年第12期1141-1149,共9页Progress In Biochemistry and Biophysics

基　　金：科技部国家重点研发计划“战略性国际科技创新合作”重点专项(SQ2018YFE020524)资助~~

摘　　要：线粒体超微结构是用电子显微镜观察到的精细结构,其可以根据不同能量需求和生理环境变化而变化,对线粒体功能具有关键调节作用.线粒体嵴结构是一种重要的线粒体超微结构,对多种线粒体疾病产生影响.因此,研究线粒体超微结构的调节机制,理解线粒体超微结构功能,对研究线粒体疾病的发病机理及寻找相关疾病的治疗靶点具有重要指导意义.本文详细介绍了线粒体嵴结构的主要调节机制,重点关注线粒体超微结构组成成分、线粒体超微结构对线粒体功能的影响、线粒体超微结构与线粒体疾病关系方面的研究进展,以期为制定更有效的线粒体疾病治疗方案提供理论参考.Mitochondrial ultrastructure is a fine structure observed by electron microscope, which can be changed according to different energy requirements and physiological environment, and plays a key role in regulating mitochondrial function. The structure of mitochondrial cristae is an important mitochondrial ultrastructure, which affects many mitochondrial diseases. Therefore, studying the function and understanding the regulation mechanism of mitochondrial ultrastructure have important guiding significance for studying mitochondrial diseases and looking for therapeutic targets. This paper introduces the main regulating mechanism of mitochondrial cristae in detail, and focuses on the research progress in the composition of mitochondrial ultrastructure, the effect of mitochondrial ultrastructure on mitochondrial function, and the relationship between mitochondrial ultrastructure and mitochondrial disease, in order to provide theoretical reference for developing more effective mitochondrial disease treatment.

关 键 词：线粒体 超微结构 嵴连接 MICOS F1F0-ATP酶 

分 类 号：Q27[生物学—细胞生物学] Q67