利用偏振光散射方法检测癌细胞  

Use Polarization Light Scattering to Detect The Cancer Cell

作　　者：孙翔宇 王勇 廖然[4,5] 孙树清[1,2] 马辉 SUNXiang-Yu;WANG Yong;LIAO Ran;SUN Shu-Qing;MA Hui(Institute of Optical Imaging and Sensing,Shenzhen Key Laboratory for Minimal Invasive Medical Technologies,Graduate School at Shenzhen,Tsinghua University,Shenzhen 518055,China;Department of Physics,Tsinghua University,Beijing 100084,China;School of Science,Qingdao University of Technology,Qingdao 266033,China;Guangdong Engineering Center for Polarization Technologies,Graduate School at Shenzhen Tsinghua University,Shenzhen 518055,China;Division of Ocean Science and Technology,Graduate School at Shenzhen,Tsinghua University,Shenzhen 518055,China)

机构地区：[1]清华大学深圳研究生院生命与健康学部,光学成像与检测实验室,深圳518055 [2]清华大学物理系,北京100084 [3]青岛理工大学理学院,青岛266033 [4]清华大学深圳研究生院,广东省偏振光学检测与成像工程技术研究中心,深圳518055 [5]清华大学深圳研究生院,海洋科学与技术学部,深圳518055

出　　处：《生物化学与生物物理进展》2019年第12期1196-1201,共6页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金委面上项目(21874082,21573124);深圳市科技创新委基础研究学科布局项目(JCYJ20170413104646428,JCYJ20170817172150505)资助项目~~

摘　　要：血液中病变细胞的检测是疾病诊断的重要依据.在癌症的诊断过程中,血液中存在癌变细胞说明身体已经有癌变组织.因此,识别和检测这些细胞在医学上具有重要的意义.偏振是光的固有属性,可以通过检测光与物质相互作用后的偏振变化来检测物质的性质.本文首次利用偏振光散射方法对悬浮在磷酸缓冲液中的癌细胞进行研究,利用红细胞和癌细胞以及活着的癌细胞和死亡的癌细胞在偏振特征上的不同,对其进行了成功的分辨.该方法具有非侵入、无损伤、高灵敏、高分辨的特点.为癌症诊断和治疗效果评估提供新思路.The detection of diseased cells in blood is an important method in cancer diagnosis and treatment. The existence of cancerous cells in the blood indicates that the body have been already canceration. Therefore, the identification and detection of the cancerous cells has the significant meaning in the medical science. Polarization is an inherent characteristic of light. The properties of different substances can be detected by their different polarization characteristics of light. In this article,we discussed the property of the cancerous cells firstly used the polarized light scattering method. Base on the different character in polarized light, we successfully distinguished the cancerous cells and erythrocyte, the viable cancerous cell and the dead cancerous cell. This method is noninvasive, non-in, high-sensitive and high-resolution compared to other ones. It provide the new ideas for cancer diagnosis and treatment.

关 键 词：癌细胞 偏振散射 识别 

分 类 号：Q632[生物学—生物物理学] Q279