TWIK相关酸敏感K^+通道-1基因rs1275988与rs2586886位点GG基因型是发生重度阻塞性睡眠呼吸暂停的潜在危险因素  

GG Genotype at rs1275988 and rs2586886 Loci of TWIK-related Acid-sensitive K^+ Channel-1 Gene is A Potential Risk Factor for Severe Obstructive Sleep Apnea

作　　者：张德莲[1] 史甜 姚晓光[1] 李梅[1] 木拉力别克·黑扎提 李秀芳[1] 闻璐 姚灵 贺媛媛 汪迎春[1] 洪静[1] 李南方[1] ZHANG Delian;SHI Tian;YAO Xiaoguang;LI Mei;MULALIBIKE Heizhati;LI Xiufang;WEN Lu;YAO Ling;HE Yuanyuan;WANG Yingchun;HONG Jing;LI Nanfang(Hypertension Institute of Xinjiang,Hypertension Center of the People’s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院高血压中心新疆高血压研究所

出　　处：《中国医学科学院学报》2020年第1期16-23,共8页Acta Academiae Medicinae Sinicae

基　　金：新疆维吾尔自治区自然科学基金(2016D01C127)~~

摘　　要：目的通过评估TWIK相关酸敏感K+通道-1(TASK-1)基因与阻塞性睡眠呼吸暂停(OSA)的相关性,探讨OSA的发病机制。方法选取2016年4月至12月首次就诊新疆自治区人民医院高血压诊疗研究中心及睡眠中心的164例重度OSA患者和171例非OSA患者,采用KASP基因分型系统对TASK-1基因2个位点(rs1275988和rs2586886)进行基因型鉴定及病例-对照关联研究。结果当血钾<3.95 mmol/L时,rs1275988等位基因(G vs.A)(χ^2=4.474,P=0.034)、隐性模型(GG+GA vs.AA)(χ^2=4.327,P=0.038)的分布在非OSA组和重度OSA组间差异有统计学意义;rs2586886等位基因(G vs.A)(χ^2=6.345,P=0.012)及显性模型(AA+GA vs.GA)(χ^2=4.431,P=0.035)的分布在两组间差异也有统计学意义。多因素Logistic回归分析结果显示,在血钾<3.95 mmol/L的人群中,rs1275988和rs2586886两位点GG基因型是重度OSA患者的危险因素(OR=7.854,95%CI:1.710~36.000,P=0.008和OR=8.849,95%CI:1.816~43.117,P=0.007)。结论在血钾<3.95 mmol/L的人群中,TASK-1基因rs1275988和rs2586886两位点的GG基因型可能是发生重度OSA的潜在危险因素。对于携带TASK-1 GG基因型的患者,血钾维持在3.95 mmol/L以上有利于减少重度OSA的发生。Objective To explore the mechanism of obstructive sleep apnea(OSA)by assessing the association between human TWIK-related acid-sensitive K+channel-1(TASK-1)gene and OSA.Methods A total of 164 patients with severe OSA and 171 patients without OSA were recruited from the Hypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region,China,from April to December 2016.Two single nucleotide polymorphisms(rs1275988 and rs2586886)in the TASK-1 gene were selected and genotyped using a Kompetitive Allele Specific PCR genotyping system.Results In patients with blood potassium<3.95 mmol/L,the distribution of rs1275988 alleles(G vs.A)(χ2=4.474,P=0.034)and recessive model(GG+GA vs.AA)(χ^2=4.327,P=0.038)showed significant differences between severe and non-OSA groups.The distribution of rs2586886 alleles(G vs.A)(χ^2=6.345,P=0.012)and dominant model(AA+GA vs.GA)(χ^2=4.431,P=0.035)showed significant differences between severe and non-OSA groups.The Logistic regression analysis showed that the GG genotype was a risk factor for OSA patients with blood potassium<3.95 mmol/L(OR=7.854,95%CI:1.710-36.000,P=0.008;OR=8.849,95%CI:1.816-43.117,P=0.007).Conclusions Both the GG genotypes of rs1275988 and rs2586886 in the TASK-1 gene may be potential risk factors in severe OSA patients with blood potassium<3.95 mmol/L.Serum potassium>3.95 mmol/L in patients with TASK-1 GG genotype may be conducive to reducing the incidence of severe OSA.

关 键 词：TWIK相关酸敏感K^+通道-1基因 阻塞性睡眠呼吸暂停 单核苷酸多态性 血钾 

分 类 号：R767.13[医药卫生—耳鼻咽喉科] R364.4[医药卫生—临床医学]