肠道微生物与自闭症谱系障碍  

Gut microbiota and autism spectrum disorder

作　　者：王宏波 王宇鹏 谭超超[2] 梁仙志 廖旻晶[1] 叶湘漓[1] WANG Hongbo;WANG Yupeng;TAN Chaochao;LIANG Xianzhi;LIAO Minjing;YE Xiangli(College of Medicine,Hu′nan Normal University,Changsha,Hu′nan 410013,China;不详)

机构地区：[1]湖南师范大学医学院,湖南长沙410013 [2]湖南省人民医院(湖南师范大学第一附属医院),湖南长沙410005

出　　处：《中国微生态学杂志》2020年第1期104-107,共4页Chinese Journal of Microecology

基　　金：国家自然科学基金(81270291);国家出国留学基金(201708430158);湖南省教育厅科学研究项目重点项目(18A028);湖南省自然科学基金(2016JJ6098)

摘　　要：自闭症谱系障碍(autism spectrum disorder,ASD)是一种精神致残的重要疾病,严重影响儿童身心健康,给家庭和社会带来沉重的负担。患者常出现不同程度胃肠道症状和伴有肠道微生物组成的改变,以此为切入点,近年越来越多的研究聚焦于ASD和肠道微生物的关系上。本文介绍了肠道微生物组成、肠―脑轴及ASD患者肠道微生物的主要变化,并从多个方面阐述了ASD与肠道微生物的关系。Autism spectrum disorder(ASD) is an important mental disability disease that seriously affects the physical and mental health of children and places a heavy burden on families and society. In recent years, more and more researches have focused on the relationship between ASD and gut microbiota in patients with ASD as it may cause varying degrees of gastrointestinal symptoms and changes in gut microbiota composition. This article describes the gut microbiota composition, gut-brain axis and major changes of gut microbiota in ASD patients, and elaborates the relationship between ASD and gut microbiota in many aspects.

关 键 词：自闭症谱系障碍 肠道微生物 肠-脑轴 

分 类 号：R37[医药卫生—病原生物学]