Application of persulfate in low-temperature atmospheric-pressure plasma jet for enhanced treatment of onychomycosis  

作　　者：Qunxia ZHANG Cao FANG Zhu CHEN Qing HUANG 张群霞;方草;陈祝;黄青(Key Laboratory of High Magnetic Field and Ion Beam Physical Biology,Institute of Technical Biology and Agriculture Engineering,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei 230031,People’s Republic of China;University of Science and Technology of China,Hefei 230026,People’s Republic of China;Anhui Jianzhu University,Hefei 230601,People's Republic of China)

机构地区：[1]Key Laboratory of High Magnetic Field and Ion Beam Physical Biology,Institute of Technical Biology and Agriculture Engineering,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei 230031,People’s Republic of China [2]University of Science and Technology of China,Hefei 230026,People’s Republic of China [3]Anhui Jianzhu University,Hefei 230601,People's Republic of China

出　　处：《Plasma Science and Technology》2020年第2期87-94,共8页等离子体科学和技术（英文版）

基　　金：We would like to thank Mr Chuankai Xia and Dr Chunjun Yang for providing Trichophyton rubrum;A portion of this work(ESR measurement)was performed with assistant of Dr Wei Tong on the Steady High Magnetic Field Facilities,High Magnetic Field Laboratory,CAS;This work is supported by National Natural Science Foundation of China(Nos.11635013 and 11775272).

摘　　要：Fungal infection of human nails,or onychomycosis,affects 10%of the world's adult population,but current therapies have various drawbacks.In this work,we employed a self-made low-temperature plasma(LTP)device,namely,an atmospheric-pressure plasma jet(APPJ)device to treat the nails infected with Trichophyton rubrum(T.rubrum)with the aid of persulfate solution.We found that persulfate solution had a promoting effect on plasma treatment of onychomycosis.With addition of sodium persulfate,the APPJ therapy could cure onychomycosis after several times of treatment.As such,this work has demonstrated a novel and effective approach which makes good use of LTP technique in the treatment of onychomycosis.

关 键 词：low-temperature plasma(LTP) PERSULFATE ONYCHOMYCOSIS Trichophyton rubrum(T rubrum) 

分 类 号：R756.4[医药卫生—皮肤病学与性病学] O53[医药卫生—临床医学]