Interactions of drug-metabolizing enzymes with the Chinese herb Psoraleae Fructus  

作　　者：ZHOU Qi-Hang ZHU Ya-Di ZHANG Feng SONG Yun-Qing JIA Shou-Ning ZHU Liang FANG Sheng-Quan GE Guang-Bo 

机构地区：[1]Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai 200000,China [2]Translational Medicine Center,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200000,China [3]Qinghai Hospital of Traditional Chinese Medicine,Xining 810000,China

出　　处：《Chinese Journal of Natural Medicines》2019年第11期858-870,共13页中国天然药物（英文版）

基　　金：supported by the NSF of China(Nos.81922070,81973286,81773687);the National Key Research and Development Program of China(No.2017YFC1700200,2017YFC1702000);Program of Shanghai Academic/Technology Research Leader(No.18XD1403600);Shuguang Program(No.18SG40);Program for applied basic research of Qinghai Provincial Science and Technology Department(No.2017-ZJ-713);Program for Innovative Leading Talents of Qinghai Province(2018&2019)

摘　　要：Psoraleae Fructus(the dried fruits of Psoralea corylifolia), one of the most frequently used Chinese herbs in Asian countries, has a variety of biological activities. In clinical settings, Psoraleae Fructus or Psoraleae Fructus-related herbal medicines frequently have been used in combination with a number of therapeutic drugs for the treatment of various human diseases, such as leukoderma, rheumatism and dysentery. The use of Psoraleae Fructus in combination with drugs has aroused concern of the potential risks of herb-drug interactions(HDI) or herb-endobiotic interactions(HEI). This article reviews the interactions between human drug-metabolizing enzymes and the constituents of Psoraleae Fructus;the major constituents in Psoraleae Fructus, along with their chemical structures and metabolic pathways are summarized, and the inhibitory and inductive effects of the constituents in Psoraleae Fructus on human drug-metabolizing enzymes(DMEs), including target enzyme(s), its modulatory potency, and mechanisms of action are presented. Collectively, this review summarizes current knowledge of the interactions between the Chinese herb Psoraleae Fructus and therapeutic drugs in an effort to facilitate its rational use in clinical settings, and especially to avoid the potential risks of HDI or HEI through human DMEs.Psoraleae Fructus(the dried fruits of Psoralea corylifolia), one of the most frequently used Chinese herbs in Asian countries, has a variety of biological activities. In clinical settings, Psoraleae Fructus or Psoraleae Fructus-related herbal medicines frequently have been used in combination with a number of therapeutic drugs for the treatment of various human diseases, such as leukoderma, rheumatism and dysentery. The use of Psoraleae Fructus in combination with drugs has aroused concern of the potential risks of herb-drug interactions(HDI) or herb-endobiotic interactions(HEI). This article reviews the interactions between human drug-metabolizing enzymes and the constituents of Psoraleae Fructus; the major constituents in Psoraleae Fructus, along with their chemical structures and metabolic pathways are summarized, and the inhibitory and inductive effects of the constituents in Psoraleae Fructus on human drug-metabolizing enzymes(DMEs), including target enzyme(s), its modulatory potency, and mechanisms of action are presented. Collectively, this review summarizes current knowledge of the interactions between the Chinese herb Psoraleae Fructus and therapeutic drugs in an effort to facilitate its rational use in clinical settings, and especially to avoid the potential risks of HDI or HEI through human DMEs.

关 键 词：Psoraleae Fructus Cytochrome P450 enzymes(CYPs) Uridine diphosphate-glucuronosyltransferases(UGTs) Herb-drug interactions(HDI) Herb-endobiotic interactions(HEI) 

分 类 号：R965[医药卫生—药理学]