胰腺癌组织中Survivin表达与临床意义研究  

Survivin expression and its clinical significance in pancreatic cancer

作　　者：王鑫[1] 刘也夫 尚海[1] 郝志强 何忠野[1] 张闻辉[1] 傅熙博 马作红 王坤[1] 李文心 李思源 王开宇 焦奥[1] 何佳垚 韩磊 宫莉莉 华向东[1] WANG Xin;LIU Ye-fu;SHANG Hai;HAO Zhi-qiang;HE Zhong-ye;ZHANG Wen-hui;FU Xi-bo;MA Zuo-hong;WANG Kun;LI Wenxin;LI Si-yuan;WANG Kai-yu;Jiao-ao;HE Jia-yao;HAN Lei;GONG Li-li;HUA Xiang-dong(Department of Hepatobiliary and pancreatic surgery,Cancer Hospital of China Medical University,Liaoning Cancer Hospital,Shenyang 110042,China)

机构地区：[1]中国医科大学肿瘤医院、辽宁省肿瘤医院肝胆胰外科,辽宁沈阳110042 [2]北部战区总医院肝胆外科,辽宁沈阳110016 [3]北部战区总医院和平院区胸心外科,辽宁沈阳110003

出　　处：《临床军医杂志》2019年第12期1290-1292,共3页Clinical Journal of Medical Officers

摘　　要：目的探讨Survivin在人体胰腺癌组织中的表达及其临床意义。方法选取自2014年5月至2015年12月在辽宁省肿瘤医院接受治疗的33例胰腺癌患者的胰腺组织标本为观察组,另选取33份非肿瘤性胰腺组织标本为对照组。应用免疫组化S-P法对两组胰腺组织标本中的Survivin表达情况进行检测。结果观察组胰腺组织的Survivin蛋白阳性表达率为66.7%(22/33),对照组的胰腺组织未检测到Survivin表达;在观察组中,Survivin表达与肿瘤的临床病理分期、分化程度均存在显著相关性(P<0.05);Survivin表达与肿瘤部位及大小、患者性别及年龄均无显著相关性(P>0.05)。结论胰腺癌组织中的Survivin表达水平与胰腺癌的发生、发展存在密切联系,其对疾病的诊断、预后判定均具有重要意义。Objective To investigate the expression of Survivin in pancreatic cancer and its clinical significance.Methods From May 2014 to December 2015,33 pancreatic tissue samples from patients with pancreatic cancer treated were divided into the observation group,and 33 non-neoplastic pancreatic tissue samples were divided into the control group.Survivin expression in pancreatic tissue samples of two groups was detected by immunohistochemical S-P method.Results The Survivin expression rate of pancreatic tissue in the observation group was 66.7%(22/33),while Survivin expression was not detected in pancreatic tissue in the control group.In the observation group,Survivin expression was significantly correlated with the clinicopathological stage and differentiation of tumors(P<0.05).Survivin expression was not significantly correlated with tumor site and size,gender or age(P>0.05).Conclusion Survivin expression is closely related to the occurrence and progression of pancreatic cancer,which is of great significance for diagnosis and prognosis of pancreatic cancer.

关 键 词：SURVIVIN 胰腺癌 胰腺组织 表达 

分 类 号：K735.9[历史地理—历史学]