SOOJI CHIM (Koryo hand acupuncture) for perimenopausal insomnia:Evidence from actigraphy and serum hormone testing  

作　　者：Fei-Yi Zhao Jin-Hyeok Kim Li-Ping Yue Hai-Xia Yan Hua-Ling Song Yan Xu Hong Xu Yu-Fang Hong Qiang-Qiang Fu 赵非一;Jin-Kyeok Kim;岳立萍;燕海霞;宋花玲;徐燕;许红;洪钰芳;付强强(上海杉达学院护理系,上海201209;上海中医药大学,上海201203;上海中医药大学附属市中医医院,上海200071;同济大学附属杨浦医院科研部,上海200090)

机构地区：[1]Nursing Department,Shanghai SANDA University,Shanghai 201209,China [2]Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China [3]Shanghai Municipal Hospital of TCM Affiliated to Shanghai TCM University,Shanghai 200071,China [4]Research Department,Yangpu Hospital,Tongji University,Shanghai 200090,China

出　　处：《World Journal of Acupuncture-Moxibustion》2019年第4期274-278,共5页世界针灸杂志（英文版）

基　　金：Supported by Traditional Chinese Medicine Research Foundation Project of Shanghai Municipal Commission of Health and Family Planning:No.ZYKC20161016;Special Project for Clinical Research,Shanghai Municipal Health Commission:No.20174Y0009

摘　　要：Objective:This study is conducted to determine the effects of SOOJI CHIM(Koryo hand acupuncture,KHA)therapy on sleep structures and perimenopause symptoms among insomniacs.Methods:Totally 49 participants who met the inclusion criteria were enrolled in a two-arm randomized,placebo controlled,patients-blind trial,with 24 cases allocated to a real-KHA group and 25 cases allocated to a sham-KHA group.Patients in each group received corresponding treatment every other day,three times a week for total eight weeks.Both actigraphy and testing of serum hormones level reflected by biological markers such as follicle-stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E2)were performed at pre-and post-treatment.Additionally,the scores of Pittsburgh sleep quality index(PSQI)was used for assessing the subjective sleep experience of insomniacs.Meanwhile,adverse effects were monitored and recorded.Results:After eight-week treatment,the global scores of PSQI declined significantly(P<0.05)in the realKHA group but not in the sham-KHA group(P>0.05).According to the outcomes of actigraphy,a striking increase was observed in both sleep efficiency(SE)and total sleep time(TST)in the real-KHA group(both P<0.05)but not in the sham-KHA group(P>0.05).However,no significant changes of sleep awakenings(SA)in both groups was found after treatment(both P>0.05).Meanwhile,FSH and LH in the real-KHA group decreased markedly after intervention(both P<0.05)while those indicators only slightly changed in the sham-KHA group(P>0.05).The fluctuation of E2 levels were not significant in both groups(both P>0.05).No serious adverse event was reported in either real-or sham-KHA group.Conclusion:KHA may be a potential alternative therapy for improving perimenopausal insomnia via down regulating the levels of FSH and LH.Objective: This study is conducted to determine the effects of SOOJI CHIM（Koryo hand acupuncture, KHA）therapy on sleep structures and perimenopause symptoms among insomniacs.Methods: Totally 49 participants who met the inclusion criteria were enrolled in a two-arm randomized,placebo controlled, patients-blind trial, with 24 cases allocated to a real-KHA group and 25 cases allocated to a sham-KHA group. Patients in each group received corresponding treatment every other day, three times a week for total eight weeks. Both actigraphy and testing of serum hormones level reflected by biological markers such as follicle-stimulating hormone（FSH）, luteinizing hormone（LH） and estradiol（E2） were performed at pre-and post-treatment. Additionally, the scores of Pittsburgh sleep quality index（PSQI） was used for assessing the subjective sleep experience of insomniacs. Meanwhile, adverse effects were monitored and recorded.Results: After eight-week treatment, the global scores of PSQI declined significantly（P<0.05） in the realKHA group but not in the sham-KHA group（P>0.05）. According to the outcomes of actigraphy, a striking increase was observed in both sleep efficiency（SE） and total sleep time（TST） in the real-KHA group（both P<0.05） but not in the sham-KHA group（P>0.05）. However, no significant changes of sleep awakenings（SA） in both groups was found after treatment（both P>0.05）. Meanwhile, FSH and LH in the real-KHA group decreased markedly after intervention（both P<0.05） while those indicators only slightly changed in the sham-KHA group（P>0.05）. The fluctuation of E2 levels were not significant in both groups（both P>0.05）. No serious adverse event was reported in either real-or sham-KHA group.Conclusion: KHA may be a potential alternative therapy for improving perimenopausal insomnia via down regulating the levels of FSH and LH.

关 键 词：Perimenopausal insomnia SOOJI CHIM(Koryo hand acupuncture KHA) ACTIGRAPHY Serum hormone testing 

分 类 号：R246.6[医药卫生—针灸推拿学]