川东北地区成年体检者血浆同型半胱氨酸分布及与生化指标的关系  

The Distribution of Plasma Homocysteine and Its Relationship with Biochemical Indexes hin Adult Physical Examinees in Northeastern Sichuan

作　　者：杨尚瑜 邓健康[1,2] 李雪 黄小娟[1,2] 宋远坤 徐文莉 Yang Shangyu;Deng Jiankang;Li Xue(Department of Laboratory Medicine,Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan 637000;School of Laboratory Medicine,Translational Medicine Research Center,North Sichuan Medical College,Nanchong,Sichuan 637000,China)

机构地区：[1]川北医学院附属医院检验科,四川南充637000 [2]川北医学院医学检验系,转化医学研究中心,四川南充637000

出　　处：《四川医学》2020年第1期48-51,共4页Sichuan Medical Journal

摘　　要：目的了解川东北地区成年体检者血浆同型半胱氨酸(HCY)在不同年龄和性别中检出结果情况及与其他生化指标的关系。方法回顾性分析川北医学院附属医院体检中心的31378例体检者HCY和其他生化结果。结果HCY在川东北地区人群中呈正偏态分布,总人群检测中位数为11.00μmol/L,男女性别组检出中位数分别为12.2μmol/L和9.5μmol/L,经秩和检验比较差异有统计学意义(Z=-81.59,P=0.00)。以>15μmol/L为异常,总人群异常检出率为14.43%,男女性别组分别为21.70%(3960例)和4.33%(568例)经卡方检验比较差异有统计学意义(χ~2=1873.58,P=0.00);在各年龄阶段男性异常检出率均高于女性,且随年龄增加异常检出率有增加趋势。经相关分析知HCY与性别和肌酐呈中等程度的相关(r=-0.46,r=0.45),与空腹血糖没有相关性。结论川东北地区人群的HCY值偏高,异常检出率也高男性检测结果高于女性,多关注男性的HCY值,以期减少脑卒中和其他疾病的发生。Objective To investigate the detection results of plasma homocysteine(HCY) in different ages and genders and its relationship with other biochemical indicators in adult Physical Examinees in northeastern Sichuan.Methods A retrospective analysis was performed on the HCY and other biochemical results of 31,378 physical examinees in the Physical Examination Center of the Affiliated Hospital of North Sichuan Medical College.Results HCY showed a positively skewed distribution in the population of northeastern Sichuan.The median detection rate of the total population was 11.00 μmol/L,and the median detection rates of the male and female sex groups were 12.2 μmol/L and 9.5μmol/L,respectively.The difference was statistically significant(Z=-81.59,P=0.00).With>15 μmol/L as the abnormality,the abnormality detection rate of the total population was 14.43%,and the male and female gender groups were 21.70%(3960 cases) and 4.33%(568 cases).The difference was statistically significant by chi-square test(χ~2=1873.58,P=0.00),the abnormal detection rate of males was higher than that of females at all ages,and the abnormal detection rate increased with age.Correlation analysis showed that HCY with gender and creatinine were moderately correlated(r=-0.46,r=0.45),and had no correlation with fasting blood glucose.Conclusion HCY of the population in northeastern Sichuan is relatively high,and the abnormal detection rate is also high.Moreover,men are higher than women.Pay more attention to HCY of men in order to reduce the incidence of stroke and other diseases.

关 键 词：血浆同型半胱氨酸 分布 体检人群 

分 类 号：R446.112[医药卫生—诊断学]