基于氟尿嘧啶类药物化疗的异常糖链糖蛋白在胃肠道恶性肿瘤中表达  

Clinical Study on Expression of Tumor Abnormal Glycoproteins in Patients with Gastrointestinal Malignancies after Fluorouracil-based Chemotherapy

作　　者：印妮[1] 王雨雯 唐雨曼 朱彦博[1] 王振欣[1] YIN Ni;WANG Yu-wen;TANG Yu-man;ZHU Yan-bo;WANG Zhen-xin(Department of Oncology,First Affiliated Hospital of Soochow University,Suzhou 215006,China)

机构地区：[1]苏州大学附属第一医院肿瘤内科

出　　处：《中国药学杂志》2019年第24期2093-2096,共4页Chinese Pharmaceutical Journal

摘　　要：目的了解肿瘤异常糖链蛋白(TAP)在基于氟尿嘧啶类药物化疗的胃肠道恶性肿瘤患者外周血中的表达情况,探讨影响其表达的因素及临床意义。方法本研究纳入2018年5月至12月病理诊断确诊为胃癌及结直肠癌患者99例,其中氟尿嘧啶联合紫杉醇治疗后的胃癌患者53例,氟尿嘧啶联合奥沙利铂治疗后的结直肠癌患者46例,检测其TAP值,收集患者的基本资料、癌种、分期及血清肿瘤标记物等情况,分析TAP在不同特征消化道肿瘤中的表达差异。结果 TAP在基于氟尿嘧啶类药物化疗的胃肠道恶性肿瘤患者外周血中的表达值为(158. 11±33. 63),TAP值的表达在不同性别、年龄、癌种、临床分期及血清肿瘤标记物表达情况之间无统计学差异。结论 TAP在基于氟尿嘧啶类药物化疗的胃肠道恶性肿瘤患者中表达无差异,还不能作为鉴别诊断不同特征的消化道恶性肿瘤的依据。OBJECTIVE To acquire the expressing information about tumor abnormal glycoprotein( TAP) in the peripheral blood of the gastric cancer patients who are treated with fluorouracil and the colorectal cancer patients treated with fluorouracil,and to discuss the factors that affect its expression and its clinical significance. METHODS This research was conducted on the basis of 99 gastric cancer patients and colorectal cancer patients whose diseases were pathologically diagnosed from May to December,2018,including 53 gastric cancer patients treated with fluorouracil and paclitaxel and 46 colorectal cancer patients treated with fluorouracil and oxaliplatin.It tested their TAP values,collected the basic information,the type of the cancer,the stage of the cancer,serum tumor markers,etc.of the patients as well as analyzed the differences of the expression of TAP in gastrointestinal tumors with different characteristics.RESULTS The expression value of TAP in the peripheral blood of the gastrointestinal cancer patients is( 158. 11 ± 33. 63),and the expression of TAP value has no statistical differences in the expression of different sexes,ages,types of the cancer,clinical stages and serum tumor markers. CONCLUSION The fact that the expression of TAP has no differences in the gastrointestinal cancer patients with different characteristics can’ t be taken as the basis of identifying or diagnosing gastrointestinal tumors which are different in character.

关 键 词：肿瘤异常糖链蛋白 氟尿嘧啶 胃癌 结直肠癌 表达差异 

分 类 号：R95[医药卫生—药学]