ABCB1 C3435T基因多态性对患者术后镇痛效果的影响  

Effect of ABCB1 C3435T genetic polymorphism on efficacy of postoperative analgesia

作　　者：张雪莹 梁永新[2] 温翠丽[2] 夏婧[2] 褚海辰[2] Zhang Xueying;Liang Yongxin;Wen Cuili;Xia Jing;Chu Haichen(Department of Medicine,Qingdao University,Qingdao 266000,China;Department of Anesthesiology,Affiliated Hospital of Qingdao University,Qingdao 266000,China)

机构地区：[1]青岛大学医学部,266000 [2]青岛大学附属医院麻醉科,266000

出　　处：《中华麻醉学杂志》2019年第9期1085-1087,共3页Chinese Journal of Anesthesiology

基　　金：国家自然科学基金(8187050711)。

摘　　要：目的评价ATP结合盒B亚家族成员1转运蛋白基因C3435T(ABCB1 C3435T)基因多态性对患者术后镇痛效果的影响。方法拟行全身麻醉下胸腔镜肺叶切除术患者100例,年龄18~60岁,ASA分级Ⅱ或Ⅲ级,对基因突变型进行检测,按照基因型分为野生型纯合子组(CC组)、突变型杂合子组(CT组)和突变型纯合子组(TT组)。术后采用舒芬太尼行PCIA。记录术后24、48 h时VAS评分、术后舒芬太尼用量和术后24 h睡眠质量评分和状态特质焦虑量评分。结果与CC组比较,TT组和CT组术后24 h时VAS评分和舒芬太尼用量降低,TT组状态特质焦虑量表评分降低,CT组状态特质焦虑量表评分升高(P<0.05);与TT组比较,CT组术后24 h时VAS评分、舒芬太尼用量和状态特质焦虑量表评分升高(P<0.05);3组睡眠质量评分比较差异无统计学意义(P>0.05)。结论ABCB1 C3435T基因多态性可能是患者术后镇痛效果个体差异的机制之一。Objective To evaluate the effect of ATP-binding cassette B subfamily member 1 transporter(ABCB1)C3435T genetic polymorphism on the efficacy of postoperative analgesia.Methods One hundred American Society of Anesthesiologists physical statusⅡorⅢpatients,aged 18-60 yr,scheduled for elective thoracoscopic lobectomy under general anesthesia,were enrolled in this study.The gene mutation of ABCB1 C3435T was detected,and the patients were divided into 3 groups according to the genotypes:wild homozygote group(CC group),mutation heterozygote(CT group)and mutation homozygote group(TT group).Patient-controlled intravenous analgesia was performed with sufentanil after operation.Visual analogue scale(VAS)scores at 24 and 48 h after operation,postoperative consumption of sufentanil,sleep quality score at 24 h after operation and state-trait anxiety score were recorded.Results Compared with CC group,VAS scores at 24 h after operation and postoperative consumption of sufentanil were significantly decreased in TT and CT groups,and the state-trait anxiety score was significantly decreased in TT group and increased in CT group(P<0.05).Compared with TT group,VAS scores at 24 h after operation,postoperative consumption of sufentanil and the state-trait anxiety score were significantly increased in CT group(P<0.05).There was no significant difference in sleep quality scores among the three groups(P>0.05).Conclusion ABCB1 C3435T genetic polymorphism may be one of the mechanisms of the individual variation in the efficacy of postoperative analgesia.

关 键 词：多态性 单核苷酸 镇痛 疼痛 手术后 

分 类 号：R61[医药卫生—外科学]