PET受体显像在肥胖人群神经功能改变成像中的作用  

PET receptor imaging on neurofunctional changes in obesity

作　　者：施可欣 张晓辉 金晨涛 田梅[1] Shi Kexin;Zhang Xiaohui;Jin Chentao;Tian Mei(Department of Nuclear Medicine,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310000,China)

机构地区：[1]浙江大学医学院附属第二医院核医学科,杭州310000

出　　处：《国际放射医学核医学杂志》2019年第6期523-527,共5页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家杰出青年科学基金(81725009)。

摘　　要：全球肥胖发病率正在不断攀升,肥胖导致的各种相关疾病的发生风险也显著升高。虽然肥胖人群的大脑结构和脑区兴奋模式变化已通过一些MRI和功能MRI研究揭示,但其神经功能在分子水平上的改变尚不完全清楚。PET受体显像能够在体评估神经受体功能变化,目前已开始用于肥胖相关的神经功能研究。笔者主要综述PET受体显像在肥胖人群神经功能成像中的作用。Obesity prevalence increases worldwide,and the risk of various correlated diseases consistently grows.Although alterations in brain structure and regional activation pattern of obese individuals were widely explored in MRI and functional MRI studies,they remain incompletely understood at the molecular level.Receptor imaging with PET has been applied in obesity studies given its in vivo access to reveal brain receptor functional alterations.This article provides an overview on the role of PET brain receptor imaging in obesity.

关 键 词：肥胖症 正电子发射断层显像术 受体显像 神经功能 

分 类 号：R589[医药卫生—内分泌]