旋覆代赭汤防治化疗性呕吐的疗效观察及最佳配比研究  

Clinical effect of Xuanfu Daizhe decoction in prevention and treatment of chemotherapy-induced vomiting and the optimal ratio of inula britannical and ruddle

作　　者：钟欢[1] 李杳瑶[2] 孙铜林 刘华[2] ZHONG Huan;LI Yaoyao;SUN Tonglin;LIU Hua(Hunan University of Chinese Medicine,Changsha 410208,H unan,China;The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,Hunan,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《湖南中医杂志》2019年第12期10-13,共4页Hunan Journal of Traditional Chinese Medicine

基　　金：湖南中医药大学科研基金资助项目(编号:ZYYDX201737)

摘　　要：目的:观察旋覆代赭汤防治化疗性呕吐的疗效及其最佳配比。方法:将48例采用顺铂为主要化疗方案的恶性肿瘤患者随机分为3组,对照组采用西医常规预防呕吐治疗,治疗组在对照组治疗基础上加用旋覆代赭汤治疗,其中治疗1组旋覆花与代赭石之比为3∶1,治疗2组旋覆花与代赭石之比为1∶3,观察3组的恶心呕吐控制情况、治疗前后中医证候积分及不良反应的发生情况。结果:对于迟发性呕吐,总有效率治疗1组为87.5%,明显高于治疗2组的50.0%与对照组的37.5%,差异有统计学意义(P<0.05);对于爆发性呕吐,总有效率治疗1组为93.8%,治疗2组为87.6%,均明显高于对照组的50.0%,差异有统计学意义(P<0.05)。结论:旋覆代赭汤能有效缓解化疗患者恶心呕吐等消化道反应,且按照《伤寒论》原方中旋覆花与代赭石之比为3∶1时疗效更佳。Objective:To investigate the clinical effect of Xuanfu Daizhe decoction in the prevention and treatment of chemotherapy-induced vomiting and the optimal ratio of inula flower and red ochre.Methods:A total of 48 patients with malignant tumor who received cisplatin as the main chemoradiotherapy regimen were randomly divided into treatment group 1,treatment group 2,and control group.The patients in the control group were given conventional Western medicine therapy to prevent vomiting,and those in the treatment groups were given Xuanfu Daizhe decoction in addition to the treatment in the control group.The ratio of inula britannical and ruddle was 3∶1 for treatment group 1 and 1∶3 for treatment group 2.The three groups were compared in terms of the control of nausea and vomiting,traditional Chinese medicine syndrome score before and after treatment,and adverse events.Results:As for delayed vomiting,treatment group 1 had a significantly higher overall response rate than treatment group 2 and the control group(87.5%vs 50.0%/37.5%,P<0.05).As for fulminant vomiting,treatment group 1 had a significantly higher overall response rate than treatment group 2 and the control group(93.8%vs87.6%/50.0%,P<0.05).Conclusion:In patients receiving chemotherapy,Xuanfu Daizhe decoction can effectively alleviate gastrointestinal reactions including nausea and vomiting,with a better clinical effect at a ratio of inula britannical and ruddle of 3∶1 based on the original prescription in Treatise on Febrile Diseases.

关 键 词：呕吐 化疗 中医药疗法 旋覆代赭汤 

分 类 号：R256.31[医药卫生—中医内科学]