肺结核患者OPN与IL-17A变化的临床意义  

Clinical significance of variation of OPN and IL-17A in patients with pulmonary tuberculosis

作　　者：詹丽丽[1] 江共英 占岳芳 付雪媛 邹锦芳 ZHAN Li-li;JIANG Gong-ying;ZHAN Yue-fang;FU Xue-yuan;ZOU Jin-fang(Changshan People's Hospital,Quzhou,Zhejiang 324200,China)

机构地区：[1]常山县人民医院呼吸与危重症医学科,浙江衢州324200 [2]常山县人民医院感染科,浙江衢州324200 [3]开化县人民医院手术室,浙江衢州324300 [4]开化县人民医院儿科,浙江衢州324300 [5]开化县人民医院血透室,浙江衢州324300

出　　处：《中华医院感染学杂志》2019年第24期3701-3705,共5页Chinese Journal of Nosocomiology

摘　　要：目的探讨骨桥蛋白(osteopontin,OPN)、白细胞介素-17A (interleukin-17A,IL-17A)在肺结核患者体内变化的临床意义。方法选择2016年1月-2018年12月在常山县人民医院治疗的肺结核患者120例为研究对象。其中活动性肺结核60例,非活动性肺结核60例,另选择同期健康体检者60名为对照组。检测三组血清OPN、IL-17A水平,活动性肺结核患者治疗6个月后再次检测OPN、IL-17A检测。结果活动性肺结核患者OPN(753.3±68.1)ng/ml与IL-17A(89.1±10.6)ng/L水平高于非活动性肺结核与对照组,非活动性肺结核患者高于对照组,差异均有统计学意义(P<0.05)。活动性肺结核患者中,粟粒型肺结核患者血清OPN(982.5±113.5)ng/ml与IL-17A(138.3±19.6)ng/L水平最高,其次为空洞型肺结核,均高于浸润型肺结核患者,差异均有统计学意义(P<0.05)。活动性肺结核痰涂阳性患者血清OPN与IL-17A水平高于痰涂阴性患者,差异有统计学意义(P<0.05)。活动性肺结核治疗6个月后血清OPN(512.1±48.5)ng/ml与IL-17A(62.7±11.2)ng/L水平较治疗前下降,差异有统计学意义(P<0.05)。结论肺结核患者血清OPN、IL-17A水平升高,并且其升高与活动性、痰涂阳性、分型等有关,抗结核治疗后,其水平也有所下降。OBJECTIVE To discuss the significance of variation in levels of OPN and IL-17 A in patients with pulmonary tuberculosis. METHODS A total of 120 patients with pulmonary tuberculosis from Jan. 2016 to Dec. 2018 in Changshan People’s Hospital were recruited in this study. Among them, 60 cases were active pulmonary tuberculosis, 60 cases were inactive pulmonary tuberculosis, and 60 healthy volunteers in the same period were selected as the control group. Serum OPN and IL-17 A levels were measured in the three groups before the treatment. Levels of OPN and IL-17 A were detected again in patients with active pulmonary tuberculosis after 6 months of treatment. RESULTS The levels of OPN(753.3±68.1)ng/ml and IL-17 A(89.1±10.6)ng/L in patients with active pulmonary tuberculosis were significantly higher than that in patients with inactive pulmonary tuberculosis and the control group;the indexes in patients with inactive pulmonary tuberculosis were significantly higher than that in the control group(P<0.05). Levels of serum OPN(982.5±113.5)ng/ml and IL-17 A(138.3±19.6)ng/L were the highest in patients with Miliary tuberculosis, followed by empty pulmonary tuberculosis, which were significantly higher than that in patients with invasive pulmonary tuberculosis(P<0.05).The levels of serum OPN and IL-17 A in sputum smear positive patients with active pulmonary tuberculosis were significantly higher than that in sputum smear negative patients(P<0.05).The levels of OPN(512.1±48.5)ng/ml and IL-17 A(62.7±11.2)ng/ml in serum of patients with active pulmonary tuberculosis after 6 months of treatment were significantly lower than that before the treatment(P<0.05). CONCLUSION The levels of OPN and IL-17 A in serum of patients with tuberculosis are significantly increased, which is related to activity, typing of tuberculosis and sputum positive. After anti-tuberculosis treatment, the level of OPN and IL-17 Adecrease significantly.

关 键 词：骨桥蛋白 白细胞介素-17A 空洞型肺结核 粟粒型肺结核 浸润型肺结核 

分 类 号：R521[医药卫生—内科学]