新型人用狂犬病疫苗研究进展  

Research progress of new rabies vaccines for human use

作　　者：孙燕(综述)[1] 孟胜利(审校) Sun Yan;Meng Shengli(College of Life Scineces,South-Central University for Nationalities,Wuhan 430074,China;Laboratory 1 of Viral Vaccine,Wuhan Institute of Biological Products Co.,Ltd.,Wuhan 430207,China)

机构地区：[1]中南民族大学生命科学学院,武汉430074 [2]武汉生物制品研究所有限责任公司病毒性疫苗研究一室,430207

出　　处：《国际生物制品学杂志》2019年第6期274-278,共5页International Journal of Biologicals

摘　　要：虽然狂犬病可通过接种狂犬病疫苗来预防,但全球每年仍有超过55000人因狂犬病死亡。采用现行狂犬病疫苗的多剂接种方案,暴露前疫苗接种对大多数国家来说不具有成本效益,因此有必要开发新型狂犬病疫苗。理想的狂犬病疫苗应与现行的多剂疫苗同样安全,而且单剂接种后就能达到保护性免疫。此综述讨论了处于临床前试验和正在进行临床试验的新型狂犬病疫苗,及其替代现有狂犬病疫苗的潜力。Although rabies can be prevented by rabies vaccination,more than 55000 people still die of rabies every year in the world.With the multiple dose regimens of current rabies vaccines,pre-exposure vaccination is not cost effective for most countries.Therefore,it is necessary to develop new rabies vaccines.The ideal rabies vaccine should be as safe and effective as the current multi-dose rabies vaccine,and most importantly,be able to achieve protective immunity after single-dose vaccination.This review discusses new rabies vaccines that are in preclinical trials as well as undergoing clinical trials,and their potential for replacing current rabies vaccines.

关 键 词：狂犬病 狂犬病疫苗 暴露后预防 

分 类 号：R51[医药卫生—内科学]