灵芝洋参复合物对小鼠免疫功能的影响  

Effects of the compound of ganoderma and ginseng on the immune function in mice

作　　者：李立[1] 王亚东[1] 王海玉[1] 李江敏[1] 张焱[1] LI Li;WANG Ya-dong;WANG Hai-yu;LI Jiang-min;ZHANG Yan(Department of Toxicology,Henan Center for Disease Control and Prevention,Zhengzhou,Henan 450000,China)

机构地区：[1]河南省疾病预防控制中心毒理室

出　　处：《中国卫生检验杂志》2019年第24期2963-2965,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的 探讨灵芝洋参复合物对小鼠免疫功能的影响。方法 经口连续给予小鼠不同剂量灵芝洋参复合物,溶剂对照组给予蒸馏水,每日一次,连续30 d。检测小鼠碳廓清能力、刀豆蛋白A(Con A)诱导的小鼠脾淋巴细胞增殖能力、迟发型变态反应、抗体细胞生成、半数溶血值、小鼠腹腔巨噬细胞吞噬鸡红细胞能力及自然杀伤(NK)细胞活性。结果 0. 90 g/kg剂量组灵芝洋参复合物可明显增加溶血空斑数;0. 30 g/kg和0. 90 g/kg剂量组灵芝洋参复合物可使小鼠足趾肿胀度、半数溶血值和NK细胞活性明显增加;0. 15 g/kg、0. 30 g/kg和0. 90 g/kg剂量组灵芝洋参复合物可促进小鼠脾淋巴细胞增值能力。结论 灵芝洋参复合物对小鼠免疫功能具有增强作用。Objective To study the enhancing immune function of the compound of gancxlemia and ginseng in mice.Methods Hie mice in experimental groups were given different doses of the compound of ganoderma and ginseng by oral administration once a day.Distilled water was regarded as the solvent control.After continuous gavage administration for 30 days,the ability of mice carbon clearance,T lymphocyte proliferation of mouse spleen induced by concanavalin A(ConA),delayed hypersensitivity reaction,antibody producing cells,half hemolytic value,the ability of macrophage phagocytosis of chicken red blood cell and natural killer(NK)cell activity were measured.Results The number of hemolytic plaque was significantly increased in 0.90 g/kg group compared to solvent control group.The compound of ganoderma and ginseng could enhance toes swelling degree,half hemolytic value and NK cell activity in 0.30 g/kg and 0.90 g/kg groups.The ability of T lymphocyte proliferation significantly increased in all the three dosage groups.Conclusion Compound of ganoderma and ginseng was able to enhance the immunity function in mice.

关 键 词：灵芝 洋参 免疫功能 小鼠 

分 类 号：R285.5[医药卫生—中药学]