热毒宁注射液与利巴韦林注射液治疗病毒性肠炎的疗效对比研究  

Comparative Study on Efficacy of Reduning Injection and Ribavirin Injection in Treatment of Viral Enteritis

作　　者：王远玲 朱勇德[1] 符国平[1] 高健敏[1] WANG Yuanling;ZHU Yongde;FU Guoping;GAO Jianmin(Dept.of Emergency,the Third People s Hospital of Hainan,Hainan Sanya 572000,China)

机构地区：[1]海南省第三人民医院急诊科

出　　处：《中国医院用药评价与分析》2020年第1期80-82,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:比较热毒宁注射液与利巴韦林注射液治疗病毒性肠炎的临床疗效和安全性,为临床治疗提供参考。方法:选取2018年海南省第三人民医院急诊科确诊为病毒性肠炎的患者90例,以随机数字表法分为观察组和对照组,每组45例。在对症支持治疗的基础上,观察组患者静脉滴注热毒宁注射液,对照组患者静脉滴注利巴韦林注射液;均1日1次,连续治疗3 d。比较两组患者临床疗效,临床症状、心肌酶谱指标[肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)]改善情况和不良事件发生情况的差异。结果:观察组、对照组患者的总有效率分别为97. 78%(44/45)、93. 33%(42/45),差异无统计学意义(P>0. 05);但观察组患者的治愈率、愈显率分别为57. 78%(26/45)、91. 11%(41/45),明显高于对照组的33. 33%(15/45)、73. 33%(33/45),差异均有统计学意义(P<0. 05)。治疗后,两组患者恶心、呕吐、腹泻及腹痛等症状积分和CK、CK-MB水平均明显优于治疗前,且观察组患者上述指标水平明显优于对照组,差异均有统计学意义(P<0. 05)。治疗期间,两组患者均未发生与研究药物相关的不良事件。结论:与利巴韦林注射液比较,热毒宁注射液治疗病毒性肠炎具有更好的疗效,可显著改善患者的临床症状,减轻心肌损害。OBJECTIVE: To compare the clinical efficacy and safety between Reduning injection and ribavirin injection in treatment of viral enteritis,so as to provide reference for clinical treatment. METHODS: 90 patients diagnosed with viral enteritis in emergency department of the Third People’s Hospital of Hainan in 2018 were selected and divided into observation group and control group via random number table,with 45 cases in each group. Based on symptomatic and supportive treatment,the observation group was given Reduning injection for intravenous drip,while the control group was given ribavirin injection;both groups were given once a day for 3 consecutive days. Differences in clinical efficacy,clinical symptoms,improvements of myocardial enzyme indices [creatine kinase( CK),creatine kinase-isoenzyme( CK-MB) ]and incidences of adverse drug reactions were compared between two groups. RESULTS:The total effective rates of observation group and control group were respectively 97. 78%( 44/45) and 93. 33%( 42/45),the difference had no statistical significance( P > 0. 05);the cure rate and markedly effective rate of observation group were respectively 57. 78%( 26/45) and 91. 11%( 41/45),which were significantly higher than those of the control group [33. 33%( 15/45) and 73. 33%( 33/45) ],with statistically significant differences( P <0. 05). After treatment,the symptom scores of nausea,emesis,diarrhea,stomachache and levels of CK and CK-MB of both groups were significantly better than those of before treatment,and those of the observation group were significantly better than the control group,with statistically significant differences( P < 0. 05). During treatment,no adverse events related to the drugs occurred in both groups. CONCLUSIONS: Compared with ribavirin injection,Reduning injection has better efficacy in treatment of viral enteritis,which can effectively improve patients’ symptoms and relieve myocardial injury.

关 键 词：热毒宁注射液 利巴韦林注射液 病毒性肠炎 疗效观察 

分 类 号：R932[医药卫生—生药学] R978.7[医药卫生—药学]