葛根芩连汤联合阿托伐他汀对老年冠心病合并高脂血症病人血脂水平的影响  

Influences of Gegen Qinlian Decoction Combined with Atorvastatin on Blood Lipid Level in Elderly Patients with Coronary Heart Disease and Hyperlipidemia

作　　者：费香勇 刘贵 FEI Xiangyong;LIU Gui(People′s Hospital of Hongze District,Huai′an 223100,Jiangsu,China)

机构地区：[1]江苏省淮安市洪泽区人民医院

出　　处：《中西医结合心脑血管病杂志》2020年第2期212-215,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的研究葛根芩连汤联合阿托伐他汀对老年冠心病合并高脂血症病人血脂水平的影响。方法选择我院2016年1月—2017年6月收治的138例老年冠心病合并高脂血症病人作为研究对象,采用随机数字表法分为对照组与观察组,每组69例。两组均采用常规西药治疗,对照组采用阿托伐他汀治疗,观察组采用阿托伐他汀联合葛根芩连汤治疗,4周为1个疗程,连续治疗2个疗程。比较两组治疗前后血脂水平[总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)]、肝肾功能[血肌酐(SCr)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)]以及中医证候评分和心血管不良事件发生情况,并评价治疗效果。结果治疗后,两组中医证候评分均明显减少,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组TC、TG、LDL-C含量低于对照组;HDL-C含量高于对照组,差异有统计学意义(P<0.05);治疗前后两组血清SCr、ALT、AST比较,差异无统计学意义(P>0.05);对照组心血管不良事件发生率为10.14%,观察组为4.35%,差异无统计学意义(P>0.05);观察组总有效率为97.10%,高于对照组的86.96%,差异有统计学意义(P<0.05)。结论采用葛根芩连汤联合阿托伐他汀治疗老年冠心病合并高脂血症,疗效显著,能够明显改善病情以及临床症状,并改善脂代谢,且不良反应少。Objective To study the effect and safety of Gegen Qinlian decoction combined with atorvastatin on blood lipid level in elderly patients with coronary heart disease and hyperlipidemia.Methods One hundred and thirty-eight elderly patients with coronary heart disease and hyperlipidemia treated in our hospital from January 2016 to June 2017 were selected,and divided into control group and observation group by the random digital table method,with 69 cases in each group.The patients in two groups were treated with conventional western medicine,the patients in control group were treated with atorvastatin,and the patients in observation group were treated with atorvastatin combined with Gegen Qinlian decoction,with 1 course for 4 weeks,and 2 courses of treatment were continuously treated.The blood lipid levels[total cholesterol(TC),triacylglycerol(TG),high density lipoprotein cholesterol(HDL-C),and low density lipoprotein cholesterin(LDL-C)],liver and kidney function[serum creatinine(SCr),alanine aminotransferase(ALT),and aspartic aminotransferase(AST)],the TCM symptom scores and adverse cardiovascular events were compared between the two groups before and after treatment.Results After treatment,the score of TCM syndrome in two groups was significantly reduced,and the score of observation group was lower than that of the control group(P<0.05);After treatment,the serum TC and LDL-C contents in two groups decreased,and the content in observation group was lower than that in control group,while the HDL-C content in two groups increased,and the HDL-C content in observation group was higher than that in control group(P<0.05);There were no significant changes in serum SCr,ALT,and AST before and after treatment in two groups(P>0.05).The incidence of adverse cardiovascular events in control group was 10.14%,and the incidence of observation group was 4.35%(P<0.05).The effective rate of observation group was higher than that of the control group(97.10%vs 86.96%,P<0.05).Conclusion Gegen Qinlian decoction combined with atorvastatin

关 键 词：冠心病 高脂血症 葛根芩连汤 阿托伐他汀 不良反应 

分 类 号：R541.4[医药卫生—心血管疾病] R256.2[医药卫生—内科学]