冠心病稳定型心绞痛(阳虚脉阻证)病人NO、IL-1、IL-6、vWF水平与冠状动脉病变程度的相关性研究  

Correlation between the Levels of NO,IL-1,IL-6,vWF and the Degree of Coronary Artery Disease in Patients with Stable Angina Pectoris(Yang Deficiency and Pulse Obstruction Syndrome)

作　　者：赵国良 李达 冯振宇 闫建玲 袁长玲 杨园园 ZHAO Guoliang;LI Da;FENG Zhenyu;YAN Jianling;YUAN Changling;YANG Yuanyuan(Shanxi Province Cancer Hospital,Taiyuan 030013,Shanxi,China)

机构地区：[1]山西省肿瘤医院,太原030013 [2]山西省中西医结合医院

出　　处：《中西医结合心脑血管病杂志》2020年第2期216-218,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：山西省科技攻关项目(No.20140313008-12)

摘　　要：目的通过分析冠心病稳定型心绞痛(阳虚脉阻证)病人不同冠状动脉病变程度一氧化氮(NO)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、血管性血友病因子(vWF)水平,探讨NO、IL-1、IL-6、vWF水平与冠状动脉病变程度的相关性。方法选取2016年1月—2017年12月于山西省中西医结合医院心内科住院诊断为冠心病稳定型心绞痛(阳虚脉阻证),并行冠状动脉造影检查的病人81例,根据冠状动脉病变程度分为冠状动脉病变组与冠状动脉正常组,分别进行Gensini评分,并检测两组病人NO、IL-1、IL-6、vWF水平,分析其与冠状动脉病变程度的关系。结果冠状动脉病变组Gensini积分显著高于冠状动脉正常组(P<0.05);冠状动脉病变组NO水平显著低于冠状动脉正常组(P<0.05);IL-1、IL-6、vWF显著高于冠状动脉正常组(P<0.05);Gensini评分与IL-1、IL-6水平呈正相关,与NO水平呈负相关(P<0.05)。结论NO、IL-1、IL-6水平与冠状动脉病变程度存在一定相关性,可作为判断冠状动脉病变程度的参考指标。Objective To explore the correlation between the levels of NO,IL-1,IL-6,vWF and the degree of coronary artery disease.Methods From January 2016 to December 2017,81 patients with coronary heart disease and stable angina pectoris(yang deficiency and pulse obstruction syndrome)were diagnosed and hospitalized,and divided into coronary artery disease group and normal coronary artery group according to the degree of disease.Gensini scores were performed,and the levels of NO,IL-1,IL-6,and vWF were detected in two groups of patients.The correlation between the levels of NO,IL-1,IL-6,vWF and the degree of coronary artery disease was analyzed.Results The Gensini score of the coronary artery disease group was significantly higher than that in normal coronary artery group(P<0.05).The level of NO in the coronary artery disease group was significantly lower than that in the normal coronary artery group(P<0.05),IL-1,IL-6,and vWF levels were significantly higher than those in normal coronary arteries(P<0.05).Gensini score was positively correlated with IL-1 and IL-6 levels,and negatively correlated with NO levels(P<0.05).Conclusion There is a certain correlation between the levels of NO,IL-1,IL-6 and the degree of coronary artery disease,and they can be used as the reference index to judge the degree of coronary artery disease.

关 键 词：稳定型心绞痛 阳虚脉阻证 一氧化氮 白细胞介素-1 白细胞介素-6 血管性血友病因子 冠状动脉病变程度 相关性 

分 类 号：R541.4[医药卫生—心血管疾病] R256.2[医药卫生—内科学]