BISAP评分联合血清TG、MAP1-LC3检测对急性重症胰腺炎患者病情及预后的评估价值  

Value of BISAP score combined with serum TG and MAP1-LC3 in evaluating condition and prognosis of patients with acute pancreatitis

作　　者：陈莹 李越 CHEN Ying;LI Yue(Tieling Central Hospital,Tieling 112000,China)

机构地区：[1]铁岭市中心医院

出　　处：《山东医药》2020年第1期21-24,共4页Shandong Medical Journal

基　　金：辽宁省自然科学基金资助项目(20170540180)

摘　　要：目的探讨严重程度床边指数(BISAP)评分联合血清甘油三酯(TG)、微管相关蛋白1轻链3(MAP1-LC3)检测对急性重症胰腺炎(SAP)患者病情及预后的评估价值。方法选择169例急性胰腺炎(AP)患者,根据病情将其分为轻症AP(MAP组,n=97)和重症AP(SAP组,n=72),并于同期选取60例体检健康者为对照组。采用BISAP评分评估各组病情,用酶联免疫吸附法检测血清TG、MAP1-LC3水平,用Pearson积矩相关分析BISAP评分与血清TG、MAP1-LC3的关系。随访3个月,记录SAP患者预后,包括多器官功能障碍综合征(MODS)、胰腺坏死、死亡。绘制受试者工作特征(ROC)曲线评估BISAP评分及血清TG、MAP1-LC3对SAP患者预后的预测价值。结果SAP组BISAP评分高于MAP组(P<0.05)。MAP、SAP组血清TG、MAP1-LC3水平高于对照组,且SAP组血清TG、MAP1-LC3水平高于MAP组,比较差异均有统计学意义(P均<0.05)。MAP患者BISAP评分与血清TG、MAP1-LC3水平呈正相关(r分别为0.529、0.617,P均<0.05);SAP患者BISAP评分与血清TG、MAP1-LC3呈正相关(r分别为0.683、0.725,P均<0.05)。不同预后SAP患者BISAP评分及血清TG、MAP1-LC3水平比较差异有统计学意义(P均<0.05)。BISAP评分及血清TG、MAP1-LC3对SAP患者MODS、胰腺坏死、死亡均有一定的预测价值,三指标联合检测对SAP患者预后的预测价值优于单一指标检测(P均<0.05)。结论BISAP评分联合血清TG、MAP1-LC3检测可评估SAP患者病情严重程度,预测其预后。Objective To explore the value of bedside index for severity in acute pancreatitis(BISAP)score combined with serum triglyceride(TG)and microtubule-associated protein 1 light chain 3(MAP1-LC3)in evaluating the condition and prognosis of patients with acute pancreatitis(AP).Methods Totally 169 patients with AP were divided into the mild AP(MAP group,n=97)and severe AP(SAP group,n=72)according to their condition.At the same time,60 healthy volunteers were randomly selected as the control group.BISAP score was used to evaluate the condition of each group.The serum TG and MAP1-LC3 levels were detected by enzyme-linked immunosorbent assay.Pearson product moment correlation was used to analyze the relationship between BISAP score and serum TG and MAP1-LC3.They were followed up for 3 months to record the prognosis of AP patients,including multiple organ dysfunction syndrome(MODS),pancreatic necrosis and death.The receptor operating characteristic(ROC)curve was used to evaluate the predictive value of BISAP score,serum TG and MAP1-LC3 on prognosis of AP patients.Results The BISAP score of the SAP group was higher than that of MAP group(P<0.05).The serum TG and MAP1-LC3 levels in the MAP group and SAP group were higher than those in the control group,which in the SAP group were higher than those in the MAP group(P<0.05).BISAP score was positively correlated with serum levels of serum TG and MAP1-LC3 in patients with MAP(r=0.529,0.617,both P<0.05),and BISAP score was positively correlated with serum levels of serum TG and MAP1-LC3 in patients with SAP(r=0.683,0.725,both P<0.05).There were significant differences in BISAP score,serum TG and MAP1-LC3 levels among SAP patients with different prognosis(all P<0.05).BISAP score,serum TG and MAP1-LC3 had certain predictive value for MODS,pancreatic necrosis and death in SAP patients.Compared with predictive value of single indicator,the higher predictive value of combined detection of three indicators for different prognosis of SAP patients was observed(P<0.05).Conclusion BISAP sc

关 键 词：急性重症胰腺炎 急性胰腺炎严重程度床边指数 甘油三酯 微管相关蛋白1轻链3 

分 类 号：R657.5[医药卫生—外科学]