血清IFIP-16、tTG水平与子痫前期孕妇血压和尿蛋白的关系及其诊断价值  

Relationship of serum interferon-γ-inducible protein-16, tissue transglutaminase level with blood pressure and urine protein in preeclampsia pregnant women and its predictive value analysis

作　　者：陈艳 杨柳 张云珠[2] 焦荣红[1] CHEN Yan;YANG Liu;ZHANG Yun-zhu;JIAO Rong-hong(Department of Clinical Laboratory,Shanghai Pudong New District People's Hospital,Shanghai 201200,CHINA;Department of Obstetrics and Gynecology,Shanghai Pudong New District People's Hospital,Shanghai 201200,CHINA)

机构地区：[1]上海市浦东新区人民医院检验科,上海201200 [2]上海市浦东新区人民医院妇产科,上海201200

出　　处：《海南医学》2020年第5期593-596,共4页Hainan Medical Journal

摘　　要：目的探讨血清γ干扰素诱导蛋白16(IFIP-16)、组织型转谷氨酰胺酶(tTG)水平与子痫前期孕妇血压和尿蛋白的关系,并分析血清IFIP-16、tTG对子痫前期的诊断价值。方法随机选择2015年4月至2017年12月期间在上海市浦东新区人民医院进行检查的孕妇200例为研究对象,根据最终确诊情况选取子痫前期孕妇108例,按病情严重程度分为轻度组49例、重度组59例,再从剩余孕妇中选取健康孕妇60例作为对照组,比较孕12~14周、孕20周时三组孕妇血清IFIP-16、tTG水平及收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)、24 h尿蛋白量,分析子痫前期孕妇血清IFIP-16、tTG水平与SBP、DBP、MAP、24 h尿蛋白量的关系及血清IFIP-16水平与血清tTG水平的关系;采用ROC曲线分析孕20周时血清IFIP-16、tTG对子痫前期的诊断价值。结果孕12~14周时,重度组和轻度组孕妇的血清IFIP-16和tTG水平,SBP、DBP、MAP及24 h尿蛋白量均明显高于对照组,重度组以上指标也明显高于轻度组,差异均有统计学意义(P<0.05);孕20周时,重度组和轻度组孕妇的血清IFIP-16和tTG水平,SBP、DBP、MAP及24 h尿蛋白量均明显高于对照组,重度组以上指标也明显高于轻度组,差异均有统计学意义(P<0.05);子痫前期孕妇血清IFIP-16、tTG水平与SBP、DBP、MAP及24 h尿蛋白量呈正相关(P<0.05);血清IFIP-16水平与血清tTG水平呈正相关(P<0.05);孕20周时血清IFIP-16、t TG诊断子痫前期的ROC曲线下面积分别为0.859、0.796,鉴别轻度与重度子痫前期的ROC曲线下面积分别为0.752、0.714。结论子痫前期孕妇在孕12~14周、20周时血清IFIP-16、tTG水平显著升高,与血压、24 h尿蛋白量呈正相关;孕20周时检测血清IFIP-16、tTG水平有助于子痫前期的诊断及病情评估。Objective To explore the relationship between serum levels of interferon-γ-inducible protein-16(IFIP-16),tissue transglutaminase(tTG)with blood pressure and urine protein in preeclampsia pregnant women and analyze the predictive value of serum IFIP-16 and t TG on preeclampsia.Methods A total of 200 pregnant women who were examined in Shanghai Pudong New District People’s Hospital from April 2015 to December 2017 were randomly selected as the research subjects,of which 108 preeclampsia pregnant women were selected according to the final diagnosis.The 108 patients were divided into mild group(49 patients)and severe group(59 patients)according to the severity of illness.Sixty healthy pregnant women were selected as control group.The levels of serum IFIP-16,tTG,and systolic blood pressure(SBP),diastolic blood pressure(DBP),mean arterial pressure(MAP),24 h urinary protein volume in the three groups of pregnant women at 12 to 14 and 20 gestational weeks were compared.The relationship between serum IFIP-16,tTG levels and SBP,DBP,MAP,24 h urine protein volume and the relationship between serum IFIP-16 level and serum tTG level in preeclampsia pregnant women were analyzed.The diagnostic value of serum IFIP-16,tTG in preeclampsia was analyzed by ROC curve at 20 gestational weeks.Results At 12 to 14 gestational weeks,serum IFIP-16 and tTG levels,SBP,DBP,MAP,and 24 h urinary protein volume in pregnant women of severe group and mild group were higher than those in control group,and those in severe group were higher than those in mild group,all with statistically significant differences(P<0.05).At 20 gestational weeks,serum IFIP-16 and tTG levels,SBP,DBP,MAP,and 24 h urinary protein volume in severe group and mild group were higher than those in control group,and those in severe group were higher than those in mild group,all with statistically significant differences(P<0.05).The serum levels of IFIP-16,tTG in preeclampsia pregnant women were positively correlated with SBP,DBP,MAP and 24 h urinary protein volume(P<0.05).Ther

关 键 词：子痫前期 γ干扰素诱导蛋白16 组织型转谷氨酰胺酶 血压 尿蛋白 相关性 诊断价值 

分 类 号：R714.245[医药卫生—妇产科学]