长期高效抗反转录病毒治疗对艾滋病患者免疫功能及预后的影响研究  

Effect of Long-term High-efficiency Antiretroviral Therapy on Immune Function and Prognosis of AIDS Patients

作　　者：张海生[1] ZHANG Hai-sheng(Shantou Central Hospital,Shantou,Guangdong,515031,China)

机构地区：[1]汕头市中心医院,广东汕头515031

出　　处：《黑龙江医学》2020年第2期156-159,共4页Heilongjiang Medical Journal

摘　　要：目的探讨长期高效抗反转录病毒治疗对艾滋病患者体液免疫功能及预后的影响。方法选择2017年1月-2018年12月经汕头市中心医院诊治的136例艾滋病患者,按照是否接受长期规律高效抗反转录病毒治疗将其分为观察组和对照组,每组各68例。观察组患者给予高效抗反转录病毒长期治疗,治疗药物为拉米夫定+替诺福韦+依非韦伦,持续治疗12个月为1个疗程;对照组为依从性差的患者,不给予规律性长期服药。比较两组患者治疗不同阶段期间的外周血淋巴细胞变化、患者血清炎性因子水平变化、抗体水平变化、不同病原感染患者比例。结果治疗期间,两组患者的CD4+T淋巴细胞总数及CD4/CD8比值均呈现上升趋势;治疗后6个月及12个月,观察组患者CD4+T淋巴细胞总数及CD4/CD8比值均显著高于对照组(P<0.05),观察组患者的血清CRP及TNF-α水平均显著低于对照组(P<0.05);观察组患者治疗期间总感染率(17.65%)显著低于对照组(36.76%)。结论依从长期高效抗反转录病毒治疗方案可显著改善艾滋病患者的免疫功能及降低感染率,具有重要临床推广价值。Objective To investigate the effects of long-term and high-efficiency antiretroviral therapy on humoral immune function and prognosis in AIDS patients. Methods A total of 136 AIDS patients who were treated by the hospital from January,2017 to February, 2018 were enrolled. According to whether they received long-term regular high-efficiency antiretroviral therapy,they were divided into observation group and control group, with 68 cases in each group. Patients in the observation group were given long-term treatment with high-efficiency antiretroviral therapy. The treatment was lamivudine + tenofovir + efavirenz. The treatment was continued for 12 months as a course of treatment. The control group was consisted of poorly adherent patients, and was not given regular medication for a long time. Peripheral blood lymphocyte changes during the different stages of treatment,changes in serum inflammatory factor levels, changes in antibody levels, and proportion of patients infected with different pathogens were compared between the two groups. Results During the treatment period, the total number of CD4+ T lymphocytes and CD4/CD8 ratio increased in both groups. 6 months and 12 months after treatment, the total number of CD4+ T lymphocytes and CD4/CD8 ratio were significantly higher in the observation group, compared with the control group(P<0.05). The serum CRP and TNF-α levels in the observation group were significantly lower than those in the control group(P<0.05). The total infection rate(17.65%) in the observation group was significantly lower than that in the control group(36.76%). Conclusion Compliance with long-term high-efficiency antiretroviral therapy can significantly improve the immune function and reduce the infection rate of AIDS patients, and has important clinical promotion value.

关 键 词：长期 高效抗反转录病毒 艾滋病 免疫功能 预后 

分 类 号：R512.91[医药卫生—内科学]