川黄连不同炮制品改善四氧嘧啶小鼠糖及脂代谢紊乱比较研究  

Comparison Study on the Effect of Different Processed Products of Coptidis Rhizoma on improving the Glycol Metabolism and Lipid Metabolism Disorder in Alloxan Induced Diabetic Mice

作　　者：时晓媞 吴晓青[1] 任瑶瑶[1] 蒋合众[1] 魏屹[1] 谭睿[1] Shi Xiaoti;Wu Xiaoqing;Ren Yaoyao;Jiang Hezhong;Wei Yi;Tan Rui(College of Life Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China)

机构地区：[1]西南交通大学生命科学与工程学院

出　　处：《世界科学技术-中医药现代化》2019年第8期1634-1641,共8页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家中医药管理局全国第四次中药资源普查（2017PC004）：全国第四次中药资源普查2017年度外业调查研究（沙湾区、犍为县、彭山县），负责人：谭睿;四川省中医药管理局四川中药资源普查成果转化项目（2016年）（2016Z014）：川黄连炮制品的降糖制剂产品开发研制，负责人：谭睿;四川省中医药管理局四川省中医药健康服务项（2016S20004）：四川省中医药健康服务中医药产业保护规划及宣传，负责人：谭睿

摘　　要：目的比较川黄连不同炮制品(味连、酒味连、姜味连、萸味连、雅连、酒雅连、姜雅连、萸雅连)对四氧嘧啶小鼠糖、脂代谢的药效差异。方法采用四氧嘧啶小鼠糖尿病模型,测定小鼠的血糖指标和脂代谢相关指标。结果在降糖方面,川黄连不同炮制品组与模型组比较,均有不同程度升高四氧嘧啶糖尿病小鼠空腹血清胰岛素(Ins)、降低空腹血糖(FBG)的作用,尤以萸雅连的疗效最佳;较之模型组,味连组、雅连组、姜味连组、萸雅连组糖化血清蛋白(GSP)降低显著,表明对小鼠糖代谢调节效果较好。在降脂方面,川黄连不同炮制品均可降低糖尿病小鼠血清中血清胆固醇(TG)、甘油三酯(TC)、低密度脂蛋白胆固醇(LDL-C)的含量,并增加高密度脂蛋白胆固醇(HDL-C)的含量。就总体趋势而言,雅连及其炮制品降脂作用优于味连及其炮制品。结论在降血糖方面,不同品种黄连、不同炮制品效果差异不大,以萸雅连降糖效果最为明显,在调节糖脂代谢紊乱和抗氧化方面,则雅连效果最佳。Objective To compare the effects of different processed products of Coptidis Rhizoma(Wei Lian, Jiuweilian,Jiang Weilian, Yu weilian, Yalian, Jialian, Jiang Yalian, Qi Yalian) on the metabolism of sugar and lipid in alloxan mice.Methods The mouse model of diabetes with alloxan was used to determine the blood glucose index and lipid metabolism related indicators in mice. Results In terms of hypoglycemic, compared with the model group, Coptidis Rhizoma had different effects on increasing fasting serum insulin(Ins) and reducing fasting blood glucose(FBG) in alloxan diabetic mice, especially The curative effect was the best. Compared with the model group, the glycosylated serum protein(GSP)of the Weilian group, the Yalian group, the Jiangweilian group and the Qiyalian group decreased significantly, indicating that the regulation of glucose metabolism in mice was better. In terms of lipid-lowering, Coptidis Rhizoma can reduce the content of serum cholesterol(TG), triglyceride(TC), low-density lipoprotein cholesterol(LDL-C) and increase the content of cholesterol(HDL-C) in serum of diabetic mice. As far as the overall trend was concerned, the lipid-lowering effect of Yalian and its processed products was superior to that of Weilian and its processed products. Conclusion In terms of blood sugar lowering, the effects of different varieties of berberine and different processed products are not much different. The effect of Yu weilian is the most obvious. The effect of yalian is the best in regulating the disorder of glucose and lipid metabolism and anti-oxidation.

关 键 词：川黄连 炮制品 血糖 血脂 

分 类 号：R285.5[医药卫生—中药学]