抗炎中药与阿尔茨海默病防治  

Prevention and Treatment of Alzheimer’s Disease with Anti-Inflammatory Chinese Medicine

作　　者：杨贵珍[1,2] 柯尊记 Yang Guizhen;Ke Zunji(Department of Immunology and Pathogenic Biology,School of Basic Medical Sciences,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Neuroscience Research Center,School of Basic Medical Sciences,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学基础医学院免疫学与病原生物学教研室,上海201203 [2]上海中医药大学基础医学院神经科学研究中心,上海201203

出　　处：《世界科学技术-中医药现代化》2019年第9期1917-1923,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会面上项目（31271142）：脑内NG2细胞吞噬β淀粉样蛋白能力及其代谢途径，负责人：柯尊记

摘　　要：阿尔茨海默病(Alzheimerdisease,AD)是最常见的年龄相关的神经系统退行性疾病,年龄是AD最重要的危险因素。神经递质紊乱、氧化应激、Aβ蛋白聚集、tau蛋白过度磷酸化、线粒体结构和功能异常、慢性炎症等被认为是AD的主要发病机制。炎症反应在AD的发生及进程中发挥重要作用。炎症/免疫细胞激活,细胞因子和补体系统调节功能紊乱,外周淋巴细胞的入侵对AD的发生发展产生错综复杂的影响。抗炎治疗,尤其是天然抗炎化合物在防治AD中的作用已经引起了人们的重视。本文对抗炎中药用于预防AD的研究做一小结。Alzheimer’s disease(AD)is the most common age-related neurodegenerative disease,and age is the most important risk factor for AD.Neurotransmitter disorders,oxidative stress,Aβprotein aggregation,tau hyperphosphorylation,mitochondrial structure and dysfunction,and chronic inflammation are considered to be the main pathogenesis of AD.The inflammatory response plays an important role in the occurrence and progression of AD.Inflammation/immune cell activation,cytokine and complement system regulation dysfunction,peripheral lymphocyte invasion have an intricate effect on the development of AD.Anti-inflammatory treatment,especially the role of natural anti-inflammatory compounds in the prevention and treatment of AD has attracted people’s attention.This paper made a summary of the anti-inflammatory Chinese medicine used to prevent AD.

关 键 词：阿尔茨海默病 神经系统炎症 中药 抗炎 

分 类 号：R285.5[医药卫生—中药学]