Visible-light-promoted sulfonylmethylation of imidazopyridines  

作　　者：Xia Mi Yuanfang Kong Jingyu Zhang Chao Pi Xiuling Cui 

机构地区：[1]College of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China [2]College of Chemistry,Henan Key Laboratory of Chemical Biology and Organic Chemistry,Key Laboratory of Applied Chemistry of Henan Universities,Zhengzhou University,Zhengzhou 450052,China

出　　处：《Chinese Chemical Letters》2019年第12期2295-2298,共4页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China (No.21602046);the MOST of China (No.2016YFE0132600);the Doctor’s Scientific Research Foundation of Henan University of Chinese Medicine (No.BSJJ2016-12)

摘　　要：The visible light promoted C-H sulfonylmethylation of imidazopyridines with easily accessible bromomethyl sulfones under mild reaction conditions was described.This protocol provides an effective and practical access to sulfonylmethylated imidazopyridines with good functional group tolerance.The desired products were provided in moderate to excellent yields for 50 examples at room temperature.The method could also be an attractive strategy to install a methyl group on imidazopyridines.The visible light promoted C-H sulfonylmethylation of imidazopyridines with easily accessible bromomethyl sulfones under mild reaction conditions was described.This protocol provides an effective and practical access to sulfonylmethylated imidazopyridines with good functional group tolerance.The desired products were provided in moderate to excellent yields for 50 examples at room temperature.The method could also be an attractive strategy to install a methyl group on imidazopyridines.

关 键 词：Visible light promoted IMIDAZOPYRIDINE Sulfonylmethylation Radical process DESULFONYLATION 

分 类 号：O621.25[理学—有机化学]