胃癌早期诊断与预后判断代谢组学研究进展  

Research Progress on Diagnosis and Prognosis of Gastric Cancer Based on Metabolomics

作　　者：赵丽沙 吴人照[1] 陈伟 柴可群[1] 董宇[1,2] Zhao Lisha;Wu Renzhao;Chen Wei;Chai Kequn;Dong Yu(Department of Pharmacy/Zhejiang Academy of Traditional Chinese Medicine,Hangzhou,310007;The 2ND clinical medical college/Zhejiang Chinese Medical University,Hangzhou,310053)

机构地区：[1]浙江省中医药研究院中药研究中心,杭州310007 [2]浙江中医药大学第二临床医学院,杭州310053

出　　处：《世界科学技术-中医药现代化》2019年第10期2088-2096,共9页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：浙江省自然科学基金委员会基础公益研究计划项目（LGD19C040005）：基于代谢组学技术的亚硝基胍诱导胃癌前病变大鼠模型分型研究，负责人：赵丽沙;浙江省科技厅重点研发计划项目（2015C03033）：常见恶性肿瘤中医典型证候临床诊断技术研究，负责人：柴可群

摘　　要：胃癌是最常见的消化道恶性肿瘤,其病程较长且早期无特异性症状,大多数患者被发现时已至中晚期,预后不良,因此探索非侵袭性、灵敏度高、特异性好的胃癌早期诊断及预后判断生物标志物是胃癌诊疗技术研究的关键问题。近年来,随着代谢组学技术的出现及迅猛发展,在代谢层面寻找高灵敏度和高特异性的胃癌诊断与预后判断生物标志物,已成为该研究领域的热点方向。本文从检测技术、样本数量、数据处理方法以及获得的差异代谢物及其调节的代谢通路等方面对近10年来代谢组学技术用于胃癌早期诊断与预后判断的研究与临床应用进行综述,旨在为代谢组学技术应用于胃癌早期诊断及预后判断提供参考依据。Gastric cancer is the most common malignant tumor of the digestive tract.It has a long course and no specific symptoms in the early stage.Most patients have been discovered until the advanced stage,and has poor prognosis.Therefore,exploring non-invasiveness,high sensitivity and good specificity biomarkers of early diagnosis and prognosis of gastric cancer are the key issues.In recent years,with the emergence and rapid development of metabolomics,it has become a hotspot to find high sensitivity and good specificity biomarkers for diagnosis and prognosis of gastric cancer at the metabolic level.This paper reviewed on gastric cancer based on metabolomics in the past 10 years.The research and clinical application of metabolomics technology in early diagnosis and prognosis of gastric cancer are summarized.The sample quantity,detection technology,data processing method and the obtained differential metabolites and their regulated metabolic pathways are intended to provide a reference for the application of metabolomics in the early diagnosis and prognosis of gastric cancer.

关 键 词：胃癌 早期诊断 预后判断 代谢组学 研究进展 

分 类 号：R241[医药卫生—中医诊断学]