响应曲面法优化米炒党参炮制工艺研究  

Study on the Optimization of Processing Technology of Rice fried Radix Codonopsis by Response Surface Method

作　　者：吕辰子 何美菁 王勃 孟祥龙 刘丽婷 张朔生 Lv Chenzi;He Meijing;Wang Bo;Meng Xianglong;Liu Liting;Zhang Shuosheng(College of Traditional Chinese Medicine,Shanxi University of Traditional Chinese Medicine,Jinzhong 030619,China;Oriental Medical College,Dongguk University,Gyeongsangbuk-do 38066,Korea)

机构地区：[1]山西中医药大学中药学院,晋中030619 [2]东国大学东方医学院,庆州38066

出　　处：《世界科学技术-中医药现代化》2019年第10期2225-2230,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会面上项目(81173555)：基于峻泻逐水及毒性与商陆皂苷甲变化相关的商陆炮制科学内涵的构建，负责人：张朔生;山西省科技厅重点研发计划重点项目(201603D3112002):12种优质中药饮片规范化炮制加工工艺及质量标准研究，负责人：张朔生

摘　　要：目的优选米炒党参饮片炮制工艺。方法通过单因素实验,分别考察米炒党参的炒制温度(℃)和炒制时间(T),以及药物与辅料比例三个因素对党参炔苷含量的影响。以党参炔苷含量为评价指标,采用HPLC测定方法和响应曲面试验设计方法,确定实验因素及其交互作用在工艺过程中对党参炔苷含量的影响,准确表达各因素与响应值之间的关系,以预测最佳工艺。结果米炒党参最佳炮制工艺为炮制温度182.77℃、炮制时间1.76 min、辅料与药物的比例55∶100。结论响应曲面法建立的模型预测性良好,适用于米炒党参炮制工艺优化。Objective To optimize the processing technology of rice fried Radix Codonopsis.Methods Through single factor experiment,the effects of 3 factors of rice fried Radix Codonopsis,which were processing temperature(℃),processing time(T)and the ratio of excipients to drugs,on the content of lobetyolin were investigated respectively.Taken the content of lobetyolin as the evaluation index,the HPLC and the response surface test design method were used to determine the influence of the experimental factors and their interaction on the content of lobetyolin in the process.The relationship between these factors and the response values was accurately expressed in order to predict the best technology.Results The best processing technology for rice fried Radix Codonopsis was:the processing temperature 182.77℃,the processing time1.76min,and the ratio of excipients to drugs 55∶100.Conclusion The model established by response surface method has good predictability,which is suitable for optimizing the processing technology of rice fried Radix Codonopsis.

关 键 词：党参 炮制工艺 响应曲面法 党参炔苷 

分 类 号：R283.3[医药卫生—中药学]