基于时间空间相关成像技术容积数据3D打印胎儿心脏模型的可行性研究  

Feasibility of three dimensional printing of the fetal heart using spatio-temporal image correlation data

作　　者：黄佳[1] 石华[1] 陈茜[1] 张玉国[1] 宋宏宁[2] 王浩[2] 周青[2] Huang Jia;Shi Hua;Chen Qian;Zhang Yuguo;Song Hongning;Wang Hao;Zhou Qing(Ultrasonography Center of Obstetrics and Gynecology,Renmin Hospital of Wuhan University,Wuhan 430060,China;Department of Ultrasound Imaging,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院妇产超声科,430060 [2]武汉大学人民医院超声影像科,430060

出　　处：《中华超声影像学杂志》2020年第2期110-117,共8页Chinese Journal of Ultrasonography

基　　金：国家自然科学基金(81771849)。

摘　　要：目的探讨应用基于时间空间相关成像技术(spatio-temporal image correlation,STIC)容积数据进行胎儿心脏3D打印的技术可行性。方法选择2019年2-5月在武汉大学人民医院接受胎儿心脏超声检查的结果正常胎儿8例及结果异常胎儿3例,采集常规超声心动图及STIC容积图像。以Mimics软件对STIC容积数据进行后处理建模,获取胎儿心脏及大血管形态的三维容积图像STL文件,输出文件至3D打印机,打印胎儿心脏及大血管3D模型。测量3D数字模型、打印模型及超声心动图各腔室大小及管径等参数,通过对比模型测值与源数据测值的差异来评估3D建模的准确性。结果11例胎儿均成功进行心脏建模并打印出心脏及大血管模型,可直观显示胎儿心脏腔室形态以及大血管走行。8例正常胎儿心脏与3例先天性心脏异常胎儿心脏数字模型、打印模型与常规超声心动图图像间心腔大小及大血管内径等参数测值间差异均无统计学意义(P>0.05),且一致性好,所有测值均在一致性界值范围内。结论以STIC容积图像为数据源进行胎儿心脏3D打印切实可行。Objective To investigate the feasibility of three dimensional(3D)printing fetal heart from spatio-temporal image correlation(STIC)volume-rendered data.Methods Eight fetuses with normal heart and 3 fetuses with confirmed cardiac anomalies identified by two-dimensional echocardiography from February to May 2019 in Renmin Hospital of Wuhan University were prospectively enrolled in this study.All the fetuses underwent two-dimensional(2D)echocardiography and STIC technology examination.The 3D volume images of fetal heart were post-processed by Mimics software to create images of the fetal heart in standard tessellation language format(STL).The STL file was output to the 3D printer and the 3D printing models of fetal heart and great vessels were obtained.In the process,the numerical values of each index of fetal hearts were measured from 3D digital model,3D printing models and routine echocardiography images,respectively.The accuracy of 3D modeling was assessed by comparing the measured values of the model with the measured values of the source data.Results In all the fetuses,STIC volume data of the fetal heart were successfully reprocessed and printed out,the anatomical structure and vascular course could be visually displayed.It showed no significant difference in all the heart size parameters between 3D digital model,3D printing models and routine echocardiography images(all P>0.05).Moreover,the size parameters were concordant well between the two methods,all of the data points fell within the limits of agreement.Conclusions The 3D printing of fetal heart using STIC volume images as the data source is feasible.

关 键 词：3D打印 时间空间相关成像 先天性心脏病 胎儿 

分 类 号：R44[医药卫生—诊断学] R714[医药卫生—临床医学]