磷酸根、钙离子在钛金属表面仿生矿化影响研究  

Influence of Ca^2+ and PO4^3-ions on titanium biomimetic mineralization

作　　者：舒慧宇[1] 秦航[1] SHU Hui-yu;QIN Hang(The Affiliated Nanjing Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu,China)

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)采购物流中心,江苏南京210029

出　　处：《生物医学工程与临床》2020年第1期13-18,共6页Biomedical Engineering and Clinical Medicine

摘　　要：目的研究不同预处理时间下,钙离子(Ca^2+)、磷酸根离子(PO4^3-)对钛金属表面仿生矿化性能的影响,为钛金属改性做铺垫。方法采用浓度为0.5 mol/L Na2HPO4和饱和Ca(OH)2的澄清溶液进行预磷化和预钙化处理,以预磷化和预钙化时间为参数,采用正交实验方法,利用能谱仪(EDS)、X射线衍射(XRD)分析仪、扫描电子显微镜(SEM)和傅里叶变换红外光谱(FT-IR)分析仪等检测手段对样品进行表征。比较各种不同预处理时间下样品表面矿化形貌、成分及晶体取向的差别,并分析各离子对矿化影响的各自作用和协同增效作用。结果不同预磷化、预钙化时间,对钛金属表面矿化仿生影响明显。预磷化时间越长,钙磷元素比增加;同时随着预磷化的时间延长,在同等预钙化时间下,钛片样品的表面C-O数量减少。结论Ca^2+和PO4^3-具有协同增效的作用,预磷化的样品再经预钙化处理,既可以加速钙磷层的沉积速度,又可以有效地调控钙磷晶体的生长取向。Objective To study effect of calcium ion(Ca^2+)and phosphate ion(PO4^3-)on biomimetic mineralization of titanium metal surface under different pretreatment time,and lay the groundwork for titanium metal modification.Methods The 0.5 mol/L Na2HPO4 and saturated solution of Ca(OH)2 were used to perform pre-phosphation and pre-calcification.The pre-phosphoration and pre-calcification time was taken as parameters,and orthogonal experiments was used.The energy dispersive spectroscopy(EDS),X-ray diffraction(XRD),scanning electron microscopy(SEM)and Fourier transform infrared spectroscopy(FT-IR)were used to characterize the samples.The differences of mineralization morphology,composition and crystal orientation were compared under different pretreatment times,and effects of each ion on mineralization and synergistic effects were analyzed.Results The difference of pre-phosphation and pre-calcification time showed obvious effects on mineralization bionics of titanium metal surface.The calcium-phosphorus element ratio increased with pre-phosphation time.With the same pre-calcification time,the pre-phosphation time was prolonged,and amount of C-O on surface of titanium was reduced.Conclusion It is demonstrated that Ca^2+ and PO4^3- have synergistic effect,pre-calcification of pre-phosphated samples could accelerate deposition rate of calcium and phosphorus layers,and effectively regulate growth of calcium and phosphorus crystals.

关 键 词：钙离子(Ca^2+) 磷酸根离子(PO4^3-) 预钙化 预磷化 磷灰石 钛金属 

分 类 号：R318[医药卫生—生物医学工程]