壮族PCOS患者及其亚组的临床特征分析和血清LHCGR的表达研究  

Analysis of clinical characteristics and expression of serum LHCGR in PCOS patients and its subgroups in Guangxi Zhuang nationality

作　　者：庞晓霞[1] 石凤 覃莉[1] 凌燕兰[1] 陈兴鸿 韦敬锡[1] 李秀霞[1] 罗小琼[1] 王俊利[1] PANG Xiaoxia;SHI Feng;QIN Li;LING Yanlan;CHEN Xinghong;WEI Jingxi;LI Xiuxia;LUO Xiaoqiong;WANG Junli(Reproductive Medicine Center of Affiliated Hospital,Youjiang Medical University for Nationalities,Baise 533000,China)

机构地区：[1]右江民族医学院附属医院生殖医学中心

出　　处：《右江医学》2019年第11期815-820,共6页Chinese Youjiang Medical Journal

基　　金：百色市科学研究与技术开发计划项目(百科20182508)

摘　　要：目的分析广西壮族多囊卵巢综合征(PCOS)患者及亚组的临床特征和黄体生成素--人绒毛膜促性腺激素受体(LHCGR)的表达情况。方法选择2018年5月~10月在右江民族医学院附属医院生殖医学中心就诊的壮族PCOS患者166例为病例组,并按不同标准分为亚组,选择年龄相匹配的同期就诊的172例壮族不孕患者作为对照组,免疫发光法测定所有研究对象的内分泌指标,用酶联免疫吸附试验(ELISA)检测血清中LHCGR的含量。结果 PCOS组的BMI、LH、LH/FSH、E2、T、AMH、INS和HOMA-IR均高于对照组(P<0.05)。在PCOS患者中,肥胖组的BMI、INS和HOMA-IR高于非肥胖组,而LH和LH/FSH低于非肥胖组(P<0.05);高雄激素组的LH、LH/FSH、E2、T较雄激素正常组的高(P<0.05);胰岛素抵抗组的Glu、INS和HOMA-IR均比非胰岛素抵抗组的高(P<0.05);相对于LH/FSH<2组,LH/FSH≥2组的LH、LH/FSH、E2、T和AMH升高,而BMI和FSH降低(P<0.05)。PCOS组和对照组以及PCOS患者不同分组间血清LHCGR的差异均无统计学意义(P>0.05)。结论壮族PCOS的临床表现多样,不同亚组的临床特征、生化特点差异较大;血清LHCGR的表达在PCOS及其亚组中未发现明显的作用。Objective To analyze the clinical characteristics and serum expression of LHCGR in patients with polycystic ovary syndrome and its subgroups in Guangxi Zhuang nationality.Methods From May 2018 to October 2018,166 Zhuang PCOS patients who were treated in the Reproductive Medicine Center of Youjiang Medical College for Nationalities were selected as the case group and divided into subgroups according to different criteria,and the 172 infertile patients of Zhuang nationality who were treated at the same time were selected as the control group.The endocrine indexes of all subjects were determined by immunoluminescence method,and the concentration of LHCGR in serum was detected by enzyme-linked immunosorbent assay(ELISA).Results BMI,LH,LH/FSH,E2,T,AMH,INS and HOMA-IR in PCOS group were significantly higher than those in control group(P<0.05).In PCOS patients,BMI,INS and HOMA-IR in obese group were significantly higher than those in non-obese group,while LH and LH/FSH in obese group were significantly lower than those in non-obese group(P<0.05).The LH,LH/FSH,E2,T of high androgen group was higher than that of normal androgen group(P<0.05).Glu,INS and HOMA-IR in insulin resistance group were significantly higher than those in non insulin resistance group(P<0.05).Compared with LH/FSH<2 group,LH,LH/FSH,E2,T and AMH increased,while BMI and FSH decreased in LH/FSH ≥ 2 group(P<0.05).There was no significant difference of serum LHCGR between PCOS group and control group,even between subgroup(P>0.05).Conclusion The clinical manifestations of PCOS are various,and the clinical and biochemical characteristics of different subgroups are quite different.The significant role for LHCGR in PCOS and its subgroups have not found in our study.

关 键 词：壮族 多囊卵巢综合征 亚组 临床特征 LHCGR 

分 类 号：R711.75[医药卫生—妇产科学]